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The metabolism and excretion of 1 naphthol 1 naphthyl beta d glucuronide and 1 naphthyl beta d glucoside in the mouse






Toxicology & Applied Pharmacology 67(3): 303-309

The metabolism and excretion of 1 naphthol 1 naphthyl beta d glucuronide and 1 naphthyl beta d glucoside in the mouse

Radiolabeled 1-naphthyl-.beta.-D-glucuronide and 1-naphthyl-.beta.-D-glucoside were synthesized from 1-[14C]naphthol. The fate of the 3 compounds in male mice was studied. After an oral dose of 45 mg/kg 1-naphthol, 100 mg/kg 1-naphthyl glucuronide and 100 mg/kg 1-naphthyl glucoside, 95, 93 and 81%, respectively, of the dose was eliminated 72 h after treatment. 1-Naphthyl glucoside was eliminated more slowly than the other 2 compounds. 1-Naphthol was metabolized predominantly to the sulfate and the glucuronide conjugates; a portion of 1-naphthyl glucoside was eliminated directly or cleaved and then reconjugated to form the sulfate and the glucuronide conjugates. 1-Naphthyl glucuronide was excreted as parent compound and sulfate, indicating hydrolysis and resynthesis. When the glucoside was administered at 10, 50 and 100 mg/kg, the lower doses of the glucoside were more readily eliminated in the urine. Large amounts of the parent compound were found in the excreta at the lower doses.

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Accession: 006717259



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