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The metabolism of 1 n butyl 5 5 diethyl barbituric acid n n butyl barbital in the rat 2. distribution of the drug and its metabolites in various tissues in vivo and in the isolated perfused liver system



The metabolism of 1 n butyl 5 5 diethyl barbituric acid n n butyl barbital in the rat 2. distribution of the drug and its metabolites in various tissues in vivo and in the isolated perfused liver system



Journal of Pharmacology and Experimental Therapeutics 212(1): 103-108



In the isolated perfused liver, N-n-butyl-barbitalnBB) was rapidly metabolized largely to N-(3-hydroxy-n-butyl)-barbital and its conjugate, and in smaller amounts to the corresponding ketone, all previously characterized as urinary and liver microsomal metabolites. The T1/2 of the elimination phase in the perfusate was 7 min, but significant amounts of both nBB and the metabolites were bound in the liver so that the T1/2 of nBB in the whole system was 12 min.

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