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The metabolism of allopurinol formation of allopurinol 1 riboside in purine nucleoside phosphorylase ec 2.4.2.1 deficiency


Biochemical Pharmacology 32(14): 2167-2174
The metabolism of allopurinol formation of allopurinol 1 riboside in purine nucleoside phosphorylase ec 2.4.2.1 deficiency
Allopurinol-1-riboside, a major metabolite of allopurinol, is commonly thought to be directly synthesized by purine nucleoside phosphorylase (PNP) in vivo. As this enzyme is otherwise believed to function in vivo primarily in the direction of nucleoside breakdown, high performance liquid chromatography and a conventional chromatographic method were used to determine the urinary metabolites of allopurinol in a child deficient of PNP. In this patient, .apprx. 40% of urinary allopurinol metabolites consisted of allopurinol-1-riboside, proving the possibility of indirect formation of allopurinol-1-riboside via allopurinol-1-ribotide in vivo, catalyzed by hypoxanthine guanine phosphoribosyltransferase (HGPRT) [EC 2.4.2.8) and a phosphatase.

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Accession: 006717387



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