The metabolism of proteoglycans and glycosaminoglycans in inflamed human gingiva
Embery, G.; Oliver, W.M.; Stanbury, J.B.
Journal of Periodontal Research 14(6): 512-519
ISSN/ISBN: 0022-3484 PMID: 161589 DOI: 10.1111/j.1600-0765.1979.tb00253.x
Glycosaminoglycans (GAG) and proteoglycans (PG) were extracted from both relatively uninflamed and severly inflamed human gingiva. The constituent GAG, hyaluronic acid, dermatan sulfate and chondroitin 4'-sulfate, were present in the same total amount and proportions in both tissues. The PG underwent substantial breakdown in the severely inflamed tissue as judged by anion exchange chromatography and cellulose acetate electrophoresis. Whereas the GAG remain apparently unchanged during inflammation, the protein moiety of the PG is catabolized leading to a loss of structural integrity.