EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The mitochondrial voltage dependent channel voltage dependent anion selective channel is modified asymmetrically by succinic anhydride


, : The mitochondrial voltage dependent channel voltage dependent anion selective channel is modified asymmetrically by succinic anhydride. Journal of Membrane Biology 83(1-2): 87-94

Succinic anhydride was previously shown to react with the outer mitochondrial membrane channel-forming protein, VDAC [voltage dependent anion-selective channel], resulting in the loss of its voltage dependence. The anhydride was presently added to VDAC held in a particular conformational state by means of an applied electric field. VDAC was inserted into the membranes from the cis side and the anhydride was added either to the cis or trans side. Channels modified in the open state behaved similarly whether anhydride was added to the cis or trans side. Modifications of VDAC in either of the 2 closed states did not. Modifications resulting in the loss of voltage-dependence occurred primarily when anhydride was added to the negative side of the membrane irrespective of which closed state the VDAC was in indicating that the accessibility of the gating charges alternated between the cis and trans sides as the channel's conformation was changed from one closed state to the other. Despite the pronounced asymmetry, in general the resulting channels behaved in the same way in response to either positive or negative fields. A model consistent with the results is presented which proposes that the same gating charges are responsible for channel closure at both positive and negative fields.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006719119

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Maneval, H., 1925: Capture dIchneumonides nouveaux pour la faune franYaise et note biologique sur une espece de la memo famille. Bulletin de la Societe Entomologique de France, 88-89

Yang, Ellen Y.; Guo Ross, Shirley X.; Bondy, Stephen C., 1999: The stabilization of ferrous iron by a toxic beta-amyloid fragment and by an aluminum salt. Aluminum is a recognized neurotoxin in dialysis encephalopathy and may also be implicated in the etiology of neurodegenerative disease, particularly Alzheimer's disease. Alzheimer's disease is suspected to be associated with oxidative st...

Driscoll M.S.; Thomas V.L.; Ramamurthy R.S., 1989: Polymorphonuclear leukocyte pmn function and antibody levels in premature infants with coagulase negative staphylococcal cons infections. Pediatric Research 25(4 PART 2): 269A

Gabina, D.; Sanna, S., 2002: Breeding programmes for improving the quality and safety of products. New traits, tools, rules and organization? Proceedings of the meeting of the Sub-Network on Genetic Resources of the FAO-CIHEAM Inter-Regional Cooperative Research and Development Network on Sheep and Goats, Sassari, Italy, 9-11 May 2002. This issue contains the proceedings of the meeting of the Sub-Network on Genetic Resources of FAO-CIHEAM InterRegional Cooperative Research and Development Network on Sheep and Goats, which was jointly organized by CIHEAM, FAO and Istituto Zootecn...

Hluchy, L.; Habala, O.; Simo, B.; Astalos, J.; Tran, V. D.; Dobrucky, M., 2004: Problem-solving environment for flood forecasting. This paper presents a prototype of the collaborative problem solving environment (PSE) for flood forecasting. Flood forecasting is a complex problem that requires cooperation of many scientists in different areas. To enable this cooperation in a m...

Szecsi, J.; Boson, B.; Johnsson, P.; Dupeyrot Lacas, P.; Matrosovich, M.; Klenk, H. D.; Klatzmann, D.; Volchkov, V.; Cosset, F. L., 2006: Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses. There is an urgent need to develop novel approaches to vaccination against the emerging, highly pathogenic avian influenza viruses. Here, we engineered influenza viral-like particles (Flu-VLPs) derived from retroviral core particles that mimic the...

Williamson, M., 2002: Charge controls offer wet end stability, quick ROL at NorskeCanada Crofton. Pulp and paper 76(12): 39-41

Kikuchi, M.; Kawamata, T., 1970: Effects of growing conditions upon physical properties of rice plant cultured by broadcasting-direct-sowing-method. 1. Effects of seeding depth upon the bending of rice seedlings. Rice was sown at depths of 0, 1, 2, 3, 4 or 5 cm and seedlings at the 3rd-leaf stage were sampled for height, length of the 1st leaf sheath, bending resistance and short and long diameters of stem sections. These measurements were used to calculat...

Greiff, M., S. De, 1979: Effects of carbamates on the peripheral blood and the hematopoietic organs of Gallus domesticus. Revista Facultad nacional de agronomia Medellin 32(1): 1-16

Konat G.; Clausen J., 1973: The cytochrome p 450 complex and esterase of the liver and brain in lindane aroclor 1254 and ddt induced intoxication of the mouse. Environmental Physiology & Biochemistry 3(3): 139-147