EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The mode of action of anabolic agents: the effect of testosterone on muscle protein metabolism in the female rat


British Journal of Nutrition 52(3): 515-521
The mode of action of anabolic agents: the effect of testosterone on muscle protein metabolism in the female rat
Testosterone (1 mg/kg body weight per day) given s.c. to female rats increased their growth rate and food conversion efficiency, but not their food intake compared with placebo-oil controls. A higher testosterone (10 mg/kg body wt per day) dose failed to increase the daily weight gain. The increased growth rate of the testosterone-treated rats appeared to occur in the whole body and not specifically in muscle. There were no significant changes in body composition. The gastrocnemius muscle protein fractional synthetic rate was higher in the hormone-treated rats than in controls. This contrasts with previous results for the anabolic agent, trenbolone acetate, and reflects differences in the mode of action of these 2 different steroids, both with androgenic properties. [This study has applications to animal production with emphasis on increased growth and feed conversion efficiency of farm animals.].


Accession: 006719296

PMID: 6498145

DOI: 10.1079/bjn19840119



Related references

The mode of action of anabolic agents with special reference to their effects on protein metabolism--some speculations. Current topics in veterinary medicine and animal science: 11-232, 1984

Mode of action of anabolic agents, with special reference to steroids and skeletal muscle: a summary review. 1977

Effect of anabolic agents on muscle protein metabolism in growing rats treated with glucocorticoids: a short review. Revista Espanola de Fisiologia 45 Suppl: 61-63, 1989

Metabolism and mode of action of androgens in target tissues of male rats part 2 mode of action of testosterone and 5 alpha di hydro testosterone at a cellular level on seminal vesicles and prostates of rats. Acta Endocrinologica 69(1): 165-173, 1972

Effect of anabolic agents on the heart muscle. 1. Effect of 4-chlorotestosterone acetate on protein metabolism in the rabbit heart. Arzneimittel-Forschung 13: 436-438, 1963

Effect Of Anabolic Agents On The Heart Muscle. 3. Effect Of 4-Chlorotestosterone Acetate On The Hypertrophic Growth And Protein Metabolism Of The Heart In Experimental Aortic Insufficiency. Arzneimittel-Forschung 13: 716-717, 1963

Effect of anabolic substances on protein synthesis in the endocrines and some other indices of protein metabolism in irradiated animals 19 nor d homo testosterone hormone rat. Meditsinskaya Radiologiya 12(4): 48-52, 1967

Anabolic agents--some thoughts on their mode of action. Proceedings of the Nutrition Society 37(3): 311-315, 1978

Anabolic action of testosterone propionate in intact adrenalectomized and ovariectomized female rats. Journal Of Animal Scienceppl. 1: 333-334, 1980

Metabolism and mode of action of androgens in target tissues of male rats. II. Mode of action of testosterone and 5 -dihydrotestosterone at a cellular level on seminal vesicles and prostates of rats. Acta Endocrinologica 69(1): 165-173, 1972