EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The mode of action of cyto toxic and anti tumor 1 nitro acridines 1. the 1 nitro acridines do not exert their cyto toxic effects by physicochemical binding with dna


, : The mode of action of cyto toxic and anti tumor 1 nitro acridines 1. the 1 nitro acridines do not exert their cyto toxic effects by physicochemical binding with dna. Chemico Biological Interactions 43(2): 131-150

The mode of action of cytotoxic and antitumor 1-nitroacridines and their isomeric derivatives was studied by comparing their effects in cell-free systems and towards cultured [human cervical cancer] HeLa cells, assuming that the nitroacridines considered exert cytotoxic effects by physicochemical binding with the DNA. All the nitroacridines impaired biosyntheses of DNA, RNA, and protein in cultured HeLa cells and a causal relationship between nitroacridine inhibition of macromolecular biosynthesis and lethal effects of the agents appears likely. In cell-free systems, the nitroacridines bound with 2 independent sites on the DNA, formed complexes with enhanced resistance to DNA strand separation upon melting, and inhibited the DNA polymerase reaction by altering activity of template and/or of enzyme. The 1-nitroacridines were poorly effective in cell-free systems and were the most potent inhibitors toward the growth of HeLa cells among the derivatives studied. The primary events responsible for cytotoxic effects of antitumor 1-nitroacridines and of their isomeric derivatives are probably different. The metabolic activation of 1-nitroacridines to more reactive intermediates which will attach to and alter the structure and/or function of sensitive cells is suggested.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006719324

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Charter, Cj, 2002: Davis Farmland: Rare breeds and a corn maze. Small farm today2002 19(2): 62-63

Mayr, B.; Reifinger, M.; Weissenboeck, H.; Schleger, W.; Eisenmenger, E., 1994: Cytogenetic analyses of four solid tumours in dogs. Four solid tumours (one haemangiopericytoma, one haemangioendothelioma, one spindle-cell sarcoma and one mammary carcinoma) in dogs were analysed cytogenetically. In the haemangiopericytoma, an additional small chromosomal segment was present. Ver...

Jackson, I.T.; Baghaki, S., 2009: Reconstruction of cranial bone defects using a quick-setting hydroxyapatite cement and absorbable plates. Journal of Craniofacial Surgery 20(2): 580-581

Chick, J.Forris.Beecham.; Chauhan, N.Rashmikant.; Bair, R.James.; Chauhan, V.Rashmikant., 2013: The Lady Windermere syndrome. Internal and Emergency Medicine 8(1): 83-85

Hadfield, M.G., 1967: The reproductive biology of the California vermetid gastropods Serpulorbis squamigerus (Carpenter 1857) and Petaloconchus montereyensis Dall, 1919. Diss: 4602

Quirk, M., 2002: Varicella vaccination reduces risk of herpes zoster. Lancet. Infectious Diseases 2(8): 454-454

Bailey, B.A.; Larson, R.L., 1991: Maize microsomal benzoxazinone N-monooxygenase. The benzoxazinones occur in hydroxamic acid and lactam forms in maize (Zea mays L.) tissue. The hydroxamic acid forms which possess a N-hydroxyl group are found in the highest concentration while the lactam members which lack the N-hydroxyl group...

Cheong, R.; Bergmann, A.; Werner, S.L.; Regal, J.; Hoffmann, A.; Levchenko, A., 2005: Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. Dynamic properties of signaling pathways control their behavior and function. We undertook an iterative computational and experimental investigation of the dynamic properties of tumor necrosis factor (TNF)alpha-mediated activation of the transcrip...

Manolios N.; Bakiera B.; Geczy C.L.; Schrieber L., 1991: Arachidonic acid metabolites in normal and autoimmune mice do not influence lymphocyte high endothelial venule interactions. In peripheral lymphoid organs the number of lymphocytes and the proportion of functional lymphocyte subsets are regulated by multiple factors including the control of lymphocyte migration by selective lymphocyte-high endothelial venule (HEV) inter...

Frank, J.; Zouni, A.; Van Hoek, A.; Visser, A.J.W.G.; Clarke, R.J., 1996: Interaction of the fluorescent probe RH421 with ribulose-1,5-bisphosphate carboxylase/oxygenase and with Na+,K+-ATPase membrane fragments. Fluorescence titrations have shown that the voltage-sensitive probe RH421 interacts with the water-soluble protein ribulose-1,5-bisphosphate carboxylase/oxygenase and with Na+,K+-ATPase membrane fragments. The probe exhibits significantly differen...