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The mode of action of enkephalins in the guinea pig myenteric plexus


, : The mode of action of enkephalins in the guinea pig myenteric plexus. Neuroscience Letters 10(3): 317-322

Intracellular recordings were made from ganglion cells of myenteric plexus of guinea pig ileum. Methionine-enkephalin and leucine-enkephalin activities on the nerve membrane were studied by adding them to the perfusing solution. Both opioid pentapeptides elicit concentration-dependent hyperpolarization of the membranes of neurons; met-enkephalin was about 2-4 times as potent as leu-enkephalin. The membrane hyperpolarization caused by enkephalins was reduced by the narcotic antagonists naloxone and naltrexone. The opiate-sensitive neurons may be the cholinergic efferents to the muscle layers. By hyperpolarizing these neurons, enkephalins may exert their inhibitory action. This may well explain why opiate analgesics reduce the output of acetylcholine and contractile response of this preparation when it is excited.


Accession: 006719330

PMID: 19605300

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Related references

Kosterlitz, H.W.; McKnight, A.T.; Corbett, A.D.; Gillan, M.G.; Paterson, S.J.; Robson, L.E.; Sosa, R.P., 1979: Biosynthesis of the enkephalins in the myenteric plexus of the guinea pig ileum: further analysis of the interaction of the enkephalins and their analogues with the opiate receptors. Nida Research Monograph 27: 48-53

Sakai K.K.; Shapiro R.; Hymson D.L., 1978: The action of enkephalins in the myenteric plexus. IRCS (International Research Communications System) Medical Science Library Compendium 6(11): 487

Corbett, A.D.; McKnight, A.T.; Kosterlitz, H.W., 1981: Tetraethylammonium facilitates the stimulation-evoked loss of the enkephalins from the myenteric plexus of guinea-pig ileum. The effects of electrical field stimulation on the contents of [Met]enkephalin and [Leu]enkephalin were determined in myenteric plexus-longitudinal muscle preparations of the guinea-pig small intestine. Cycloheximide (0.1 mM) was present in all ex...

Katayama Y.; Lees G.M.; Pearson G.T., 1986: Electrophysiological and morphological similarities between myenteric plexus neurons showing immunoreactivity to enkephalins and to vasoactive intestinal peptide in guinea pig isolated ileum. Journal of Physiology (Cambridge) 378: 101P

Anadón, A.; Martinez-Larrañaga, M.R., 1987: An inhibitory action of tetracyclines on guinea-pig myenteric plexus. In plexus containing preparations of the longitudinal muscle of the guinea-pig ileum, an inhibitory action of tetracyclines on twitch-responses to electrical field stimulation was found. Tetracycline, chlortetracycline, minocycline and doxycycline...

Bisschops, R.; Berghe, P.V.nden; Bellon, E.; Raeymaekers, P.; Janssens, J.; Tack, J., 2001: Optical monitoring of electrical stimulation-induced activation of in situ myenteric plexus of in situ myenteric plexus in the guinea pig jejunum. Gastroenterology 120(5 Supplement 1): A 717, April

Katayama Y.; North R.A., 1980: The action of somatostatin on neurons of the myenteric plexus of the guinea pig ileum. Intracellular recordings were made from neurons in ganglia of the myenteric plexus of the guinea pig ileum. Somatostatin (10-300 nM) was applied to the neurons by adding it to the perfusing solution or by ejecting it (charges up to 500 nC) from an...

North, R.A.; Williams, J.T., 1977: Extracellular recording from the guinea-pig myenteric plexus and the action of morphine. Extracellular recordings were made with glass suction electrodes from neurons in isolated ganglia of the myenteric plexus of the guinea-pig ileum. The activity recorded was considered to arise in neuronal somata as a consequence of the mechanical...

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