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The mode of action of ergometrine in the isolated dog coronary artery

, : The mode of action of ergometrine in the isolated dog coronary artery. European Journal of Pharmacology 64(2-3): 157-160

Coronary vasoconstrictor responses to ergometrine were examined in spiral coronary arterial preparations of dogs. Ergometrine or serotonin (5-HT) produced dose-dependent contractions of the strips. Methysergide significantly depressed the contractions induced by ergometrine or 5-HT. Dihydroergotamine and phentolamine depressed constrictor responses to ergometrine, while phenoxybenzamine did not. The 5-HT antagonistic action of phentolamine was stronger than that of phenoxybenzamine. Ergometrine may act on coronary arteries mainly through activation of 5-HT receptors.

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