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The mode of action of stigmatellin a new inhibitor of the cytochrome b c 1 segment of the respiratory chain


, : The mode of action of stigmatellin a new inhibitor of the cytochrome b c 1 segment of the respiratory chain. Biochimica et Biophysica Acta 765(2): 227-235

The new antibiotic stigmatellin, obtained from the myxobacterium Stigmatella aurantiaca, blocked electron flow in the respiratory chain of bovine heart submitochondrial particles [and Saccharomyces cerevisiae mitochondria] at the site of the cytochrome b-c1 segment. Its inhibitory potency was identical with that of antimycin and myxothiazol and, like these antibiotics, stigmatellin caused a shift in the spectrum of reduced cytochrome b. Difference spectroscopic studies with the 3 inhibitors in various combinations indicated that the binding site of stigmatellin was different from that of antimycin, but almost identical with that of myxothiazol. Experiments with 14 synthesized derivatives of stigmatellin showed that good inhibitory activity can be expected only if the side chain is relatively lipophilic, and the keto and the hydroxy groups of the chromone system are intact.

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Uei Y.; Watanabe Y.; Kokketsu H.; Hirota E.; Sano R.; Fujita K.; Watanabe H., 1971: Diagnostic cytology of breast tumors with histological bases. J Coll Sci Teach 9: 62

Picos, C. A., 1963: Action of adrenaline on the oxygen consumption of carp. Variations in O2 consumption of young carp at intervals of 1/4, 1/2, 1, 1 1/2, 2, 2 1/2 hr. in water at 20[degree]C were observed after the intraabdominal administration of a solution of 50 gamma/kilocorps of epinephrine. Energy metabolism was det...

Zhang, L. L.; Nikonov, S. S.; Bronk, P. M.; Pugh, E. N.Jr, 1997: Recovery components of fish cone photoresponses. Investigative Ophthalmology & Visual Science 38(4 PART 1-2): S614

Askew B.C., 1990: The design and synthesis of macrobicyclic hosts featuring convergent functional groups. Tetrahedron Letters 31(30): 4245-4248

Bertrand D., 1968: Remarks on cultural techniques of the ancient inhabitants of the upper valleys of the andes in the ancient empire of the incas peru bolivia. C R Seances Acad Agr Fr 54(12): 996-1001

Cowan, W.Maxwell; Kopnisky, Kathy L.; Hyman, Steven E., 2002: The human genome project and its impact on psychiatry. There has been substantial evidence for more than three decades that the major psychiatric illnesses such as schizophrenia, bipolar disorder, autism, and alcoholism have a strong genetic basis. During the past 15 years considerable effort has bee...

Tingre, A. S.; Bhoyar, S. S.; Naphade, S. A.; Shingrup, P. V.; Thakare, P. D., 2006: Crop diversification in Vidarbha region of Maharashtra: a spatio-temporal analysis. In this study an attempt was made to examine the growth rates of area, production and yield of major crops in Vidarbha region along with the trend in crop diversification and crop intensity in different districts of Vidarbha. The study revealed th...

Hartmann, T.; Eschrich, W., 1969: Translocation in red algae. Planta (Heidelberg) 85(4): 303-312

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