EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The modes of the anterior hypothalamic area as the regulatory center for the gonadotropin release


Endokrinologie 70(3): 225-235
The modes of the anterior hypothalamic area as the regulatory center for the gonadotropin release
The effects of the anterior hypothalamic area (AHA) implants of gonadal steroid estrogen and progesterone as well as the effects of electrical stimulation and electrolytic lesion confined in this area on the gonadotropin secretion were investigated in ovariectomized estradiol (20 .mu.g s.c.)-primed adult Wistar rats housed in a light and temperature controlled room. Progesterone implants evoked the rise of serum LH [luteinizing hormone] by 6 h whereas estradiol implants suppressed serum FSH by 24 h after implantation. Electrical stimulation effectively depleted both gonadotropins with a latency not shorter than 6 h. The lesion significantly prevented FSH elevation investigated at 72 h post ovariectomy and potentiated FSH secretion in response to estradiol treatment at 3 wk post ovariectomy. The result revealed the involvement of the AHA in the LH release mechanism which required progesterone activation while its involvement in the FSH regulatory mechanism depended upon estrogen. The area was elucidated as the inhibitory as well as the stimulatory loci for the feedback action of estrogen on FSH release.


Accession: 006719555

PMID: 608454



Related references

Anterior hypothalamic release of gonadotropin releasing hormone gnrh and neuropeptide y npy during the mating induced gonadotropin surge in the rabbit. Biology of Reproduction 40(SUPPL 1): 95, 1989

Functional control of the anterior hypothalamic area on gonadotropin and prolactin secretion 2. the proposal role of the anterior hypothalamic area on prolactin secretion. Yokohama Medical Bulletin 30(5-6): 71-82, 1979

Ovulatory response to gonadotropin administration in maturing rats with lesions in the anterior hypothalamic area. Biology of Reproduction 17(3): 327-332, 1977

Opioid modulation of gonadotropin releasing hormone release from the hypothalamic preoptic area in the pig. Domestic Animal Endocrinology 11(4): 375-382, 1994

Changes in gonadotropin-releasing factor content in the rat hypothalamus following electrochemical stimulation of anterior hypothalamic area and during the estrous cycle. Neuroendocrinology 12(6): 321-333, 1973

In vitro release of gonadotropin-releasing hormone from the brain preoptic-anterior hypothalamic region and pituitary of female goldfish. General and Comparative Endocrinology 81(2): 256-267, 1991

Hypothalamic control of gonadotropin release in amphibia: evidence from studies of gonadotropin release in vitro and in vivo. General and Comparative Endocrinology 23(3): 294-301, 1974

Acute hypertension increases norepinephrine release in the anterior hypothalamic area. Hypertension 25(4 Pt 2): 828-833, 1995

Effects of estradiol hypothalamic extracts and lhrh on rat anterior pituitary gland gonadotropin release in vitro before and after the pre ovulatory luteinizing hormone surge at pro estrus. Journal of Endocrinology 90(3): 345-354, 1981

Acute saline infusion decreases norepinephrine release in the anterior hypothalamic area. Hypertension 27(3 Pt 2): 578-583, 1996