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The molecular basis for the reversed root effect in the blood of the marine prosobranch buccinum undatum

Molecular Physiology 1(4): 209-212

The molecular basis for the reversed root effect in the blood of the marine prosobranch buccinum undatum

The mechanism of the reversed Root effect is an allosteric ligand interaction between Cl-, CO2 and H+ on the O2-binding sites of the respiratory pigment. Approximately 70% of the O2-binding sites of B. undatum hemocyanin are blocked at high Cl- concentration (700 mM). Low Cl- concentration (300 mM) increases the number of binding sites involved in O2 binding by as much as 48%, when blood PCO2 is increased, and pH is decreased from .apprx. 8.0-7.4.

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Accession: 006719806

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