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The occurrence of cross reactive antigens in myo cardial tissue and in streptococcus pyogenes part 4 cyto toxic effect of lymphocytes sensitized in vivo to group a streptococci on primary cultures of heart muscle cells



The occurrence of cross reactive antigens in myo cardial tissue and in streptococcus pyogenes part 4 cyto toxic effect of lymphocytes sensitized in vivo to group a streptococci on primary cultures of heart muscle cells



Zeitschrift fuer Immunitaetsforschung 153(2): 120-127



The cytotoxic effect of rat lymphocytes in vivo sensitized to group A streptococci, rat heart tissue or streptococcal M proteins was investigated in primary cultures of beating rat heart cells. Cytotoxicity was found in 75-82% of heart cell cultures in contact with lymphocytes sensitized to streptococcal whole cells or lysates and in 100% of those exposed to lymphocytes sensitized to rat heart tissue. Lymphocytes sensitized to M protein exert a cytopathic effect only in 8 and 12% of cultures, respectively, and to a much more limited extent. Controls were affected in 6%. The cytotoxicity test seems useful to examine the presence of cross-reactive antigens within streptococcal vaccines.

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