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The oncostatic effect of 1 2 chloroethyl 3 methylcyclohexyl 1 nitroso trans urea on various experimental lympho reticular neoplasms


, : The oncostatic effect of 1 2 chloroethyl 3 methylcyclohexyl 1 nitroso trans urea on various experimental lympho reticular neoplasms. Leukemia Research 6(1): 89-96

Studies on the chemotherapeutic potential of methyl-CCNU [1-(2-chloroethyl)-3-(methyl-cyclohexyl)-1-nitroso-trans-urea] on experimental leukemias were undertaken. A number of murine transplantable in vivo lines (chemical carcinogen-induced T and B leukemias; radiation- and viral-induced T leukemias of C57BL/6, C3H/eb and SJL/J origin; radiation-induced myeloid leukemias and spontaneous reticulum cell neoplasms of SJL/J mice) were used. The optimal dose of methyl-CCNU and optimal timing of administration were extensively investigated on 2 sample lines of T cell leukemias of C57BL/6 mice. Leukemic cell eradication could be achieved in almost all of the different leukemias treated, irrespective of whether induction was brought about by chemical or physical means or due to a viral leukemogenic agent. Studies undertaken to elucidate the effect of methyl-CCNU on the establishment of preleukemic cells following induction of leukemia by the radiation leukemia virus or by total body irradiation indicated the oncostatic effect of methyl-CCNU on early preleukemic cells.

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