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The one and a half syndrome a unilateral disorder of the pontine tegmentum 20 cases and a review of the literature






Neurology 33(8): 971-980

The one and a half syndrome a unilateral disorder of the pontine tegmentum 20 cases and a review of the literature

The "one-and-a-half" syndrome is a clinical disorder of extraocular movements characterized by a conjugate horizontal gaze palsy in 1 direction plus an internuclear ophthalmoplegia in the other. The syndrome is usually due to a single unilateral lesion of the paramedian pontine reticular formation or the abducens nucleus on 1 side, causing the conjugate gaze palsy. It interrupts the internuclear fibers of the ipsilateral medial longitudinal fasciculus after it crosses the midline from its site of origin in the contralateral abducens nucleus (producing failure of adduction of the ipsilateral eye). Twenty cases are reported; 14 had multiple sclerosis.

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Accession: 006728083



Related references

The one-and-a-half syndrome--a unilateral disorder of the pontine tegmentum: a study of 20 cases and review of the literature. Neurology 33(8): 971-980, 1983

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