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The one point method as clinical tool to calculate and or adjust dosage regimen


, : The one point method as clinical tool to calculate and or adjust dosage regimen. Drug Development and Industrial Pharmacy 3(6): 547-554

The 1-point method is presented as a clinical tool to calculate the dosage regimen for patients where differences in steady state blood levels are expected due to change in the volume of distribution (edema, obesity, myocardial or coronary infarction, hypoalbuminemia, displacement from protein binding, etc.). The 1-point method is based on the .**GRAPHIC**. [minimal drug concentration at steady state] and superposition methods using a single blood sample on administration of a test dose during the 1st dosing interval.

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