EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The ontogeny of growth hormone receptors in the rabbit tibia


, : The ontogeny of growth hormone receptors in the rabbit tibia. Endocrinology 122(6): 2562-2569

To address the question of the mode of action of GH in stimulating longitudinal bone growth, we have used a panel of anti-GH receptor monoclonal antibodies to demonstrate GH receptors in the rabbit tibia and have studied the ontogeny of these receptors. In the neonate, receptors were localized in the hypertrophic zone between the cartilage canals, a region that develops into a secondary ossification center. In support of this finding, receptors were also localized on monolayer cultures of human infant costal chondrocytes. In 20- and 50-day-old rabbits, receptors were localized on reserve and proliferative chondrocytes in the growth plate. In 50- and 130-day-old rabbits receptors were localized on proliferative chondrocytes in the condylar cartilage. In older (180-day-old) rabbits with closed growth plates, GH receptors could not be detected, even in condylar cartilage. These results support the case for revision of the somatomedin hypothesis to accommodate a direct interaction between GH and receptors on epiphyseal chondrocytes.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006728252

PMID: 3286226

DOI: 10.1210/endo-122-6-2562

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Neumann, D; Neumann, U., 1972: Studies and recommendations regarding cover crop growing in the pome fruit orchards of the northern counties of the German Democratic Republic. Archiv fur Gartenbau: 0 (7) 539-563

Igbeka, J. C.; Jory, M.; Griffon, D., 1992: Selective mechanization for cassava processing. Existing and prototype machines for the mechanization of gari processing from cassava were compared with traditional methods. It was found that some of the machines were operative and produced comparatively good products, but their costs and techn...

White J. E., 1984: Computed waveforms in transversely isotropic media; I, Line source and vertical point force. Colorado School of Mines Quarterly 70(2): 33-60

Ono, Yasuko; Hayashi, Chikako; Doi, Naoko; Kitamura, Fujiko; Shindo, Mayumi; Kudo, Kenichi; Tsubata, Takuichi; Yanagida, Mitsuaki; Sorimachi, Hiroyuki, 2007: Comprehensive survey of p94/calpain 3 substrates by comparative proteornics - Possible regulation of protein synthesis by p94. Calpain represents a family of Call-dependent cytosolic cysteine proteases found in almost all eukaryotes and some bacteria, and is involved in a variety of biological phenomena, including brain function. Several substrates of calpain are aggress...

Burgess, T. L.; Blazich, F. A.; Nash, D. L.; Randall Schadel, B., 2005: Influence of selected surface disinfestants, fungicides, and temperature on seed germination and initial growth of southern seaoats (Uniola paniculata). Seeds of southern seaoats (Uniola paniculata) were removed from storage at 4 degrees C and treated with the following selected surface disinfestants, fungicides or combinations of these chemicals: nontreated (control), 1.3% sodium hypochlorite (ch...

Shaverdo, EV., 2000: Life cedes and the overwintering features of Dytiscidae (Coleoptera: Adephaga) in Belarus. Five types of life cycles of Dytiscidae of Belarus have been recognized using Nilsson's classification of dytiscid life cycles. Descriptions of these types are given. The features of the phenology of some dytiscid taxons are discussed. Three...

Paul M.; Himmelstein J., 1988: Reproductive hazards in the workplace what the practitioner needs to know about chemical exposures. A growing body of scientific evidence implicates occupational chemical exposures in the etiology of human adverse reproductive outcomes. Most reproductive toxins that have been investigated in sufficient detail have been shown to exert multiple ef...

Hiramatsu, Hiroshi.; Tasaka, Kiyoshi.; Shichiri, Sigemi.; Hashizaki, Fumitaka., 1991: A case of masculinization in a female ostrich. Journal of Japanese Association of Zoological Gardens and Aquariums, 334: 81-84

Muzinic R., 1969: Observations on the reactions of the sardine sardina pilchardus to intermittent white light. FAO (Food & Agriculture Organization of the United Nations) Fisheries Reports 3(62): 861-871

Van Langevelde, P.; Balwit, J. M.; Proctor, R. A., 1993: Staphylococcus aureus gentamicin-resistant, hemin-auxotrophs persist intracellularly within bovine endothelial cells. Abstracts of the General Meeting of the American Society for Microbiology 93(0): 65