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The ontogeny of the human placental gluco corticoid receptor and inducibility of heat stable alkaline phosphatase


, : The ontogeny of the human placental gluco corticoid receptor and inducibility of heat stable alkaline phosphatase. Endocrinology 104(5): 1364-1368

The human placenta contained a cytosol receptor for glucocorticoids. The concentration of this receptor in term placenta was 27-fold higher than that found in cytosol from 1st trimester placenta. The levels of cytosol glucocorticoid receptor in 3 trophoblastic cell lines (JAr, BeWo, and JEG) were determined and all were low. The ability of prednisolone, a potent glucocorticoid, to stimulate heat-stable alkaline phosphatase activity found in these cells was tested. Although control experiments demonstrated that the conditions were adequate to stimulate HeLa cell alkaline phosphatase, none of the trophoblastic lines responded to prednisolone administration. The JAr cells lacked any detectable flucocorticoid receptor and the receptor levels in cytosol prepared from JEG and BeWo cells were 12 and 2%, respectively, of those measured in HeLa cytosol. The increase in serum levels of heat-stable alkaline phosphatase observed during pregnancy may reflect increasing placental sensitivity to glucocorticoids as a result of increased receptor levels.

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