EurekaMag.com logo
+ Translate

The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an x linked bone marrow derived cell defect


, : The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an x linked bone marrow derived cell defect. Journal of Immunology 119(6): 1874-1878

The primary in vitro antibody response of neonatal spleen cells to 3 thymic independent antigens was examined. The time of onset of responsiveness to TNP[trinitrophenylated]-Brucella abortus and TNP-[Escherichia coli]lipopolysaccharide was significantly earlier than the onset of responsiveness to TNP-Ficoll. This ontologic sequence was not affected by T [thymus-derived] cell depletion or antigen presentation on adult macrophages. In neonatal mice bearing the X-linked CBA/N defect, the response to TNP-B. abortus and TNP-lipopolysaccharide was much delayed and no response to TNP-Ficoll developed. Different thymic independent antigens address different subpopulations of B [bone marrow-derived] cells, one of which appears earlier in ontogeny than the other.

(PDF 0-2 workdays service)

Accession: 006728342

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Mosier, D.E.; Mond, J.J.; Goldings, E.A., 1977: The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an X-linked B cell defect. The primary in vitro antibody response of neonatal spleen cells to three thymic independent antigens has been examined. The time of onset of responsiveness to TNP-Brucella abortus and TNP-lipopolysaccharide was significantly earlier than the onset...

Sherr D.H.; Szewczuk M.R.; Cusano A.; Rappaport W.; Siskind G.W., 1979: Ontogeny of bone marrow derived lymphocyte function part 9 difference in the time of maturation of the capacity of bone marrow derived lymphocytes from fetal and neo natal mice to produce a heterogeneous antibody response to thymic dependent and thymic independent antigens. The ontogeny of the capacity of the B [bone marrow-derived] lymphocyte population to produce a response which is heterogeneous with respect to antibody affinity was studied in a cell transfer system. Lethally irradiated mice were reconstituted wit...

Metcalf E.S.; Scher I.; Klinman N.R., 1980: Susceptibility to in vitro tolerance induction of adult bone marrow derived cells from mice with an x linked bone marrow derived cell defect. Journal of Experimental Medicine 151(2): 486-491

Goodman, M.G.; Weigle, W.O., 1979: Thymus derived cell regulation of poly clonal bone marrow derived cell responsiveness 2. evidence for a deficit in thymus derived cell function in mice with and x linked bone marrow derived lymphocyte defect. In addition to the X-linked B [bone marrow-derived] cell maturation deficit previously reported in CBA/N mice, a functional T [thymus-derived] cell defect has now been observed. T lymphocyte regulation of the polyclonal PFC [plaque-forming cell] r...

Whitlock, C.A.; Watson, J.D., 1979: Bone marrow derived cell differentiation in the cba n mouse 1. slower maturation of mitogen and antigen responsive bone marrow derived cells in mice expressing an x linked defect. The effect of age on the mitogenic and antigenic responsiveness of B [bone marrow-derived] cells was examined in spleen cell cultures of CBA/N and (CBA/N .times. DBA/2) F1 mice. Spleen cells from young male F1 mice (4-6 wk old) show lower mitogeni...

Metcalf E.S., 1978: Functional immaturity of bone marrow derived cells in adult mice with an x linked bone marrow derived cell defect. Federation Proceedings 37(6): 1674

Coutinho A., 1976: Genetic control of bone marrow derived cell responses part 2 identification of the spleen bone marrow derived cell defect in c 3h hej mice. Scandinavian Journal of Immunology 5(1-2): 129-140

Scher I.; Sharrow S.O.; Paul W.E., 1975: Relative distribution of amount of surface immuno globulin on lymphocytes from normal mice and mice with a bone marrow derived cell defect. Federation Proceedings 34(3): 999

Goodman M.G.; Weigle W.O., 1980: Inability of thymus derived cells from mice with the cba n bone marrow derived cell defect to amplify poly clonal bone marrow derived cell responses to bacterial lipo poly saccharide. An evaluation of the ability of T [thymus-derived] cells to provide amplifier function and of B [bone marrow-derived] cells to respond to these T cell signals was conducted within the context of the CBA/N immunodeficiency model. Although B cells f...

Taurog J.D.; Moutsopoulos H.M.; Rosenberg Y.J.; Chused T.M.; Steinberg A.D., 1979: Cba n x linked bone marrow derived cell defect prevents nzb bone marrow derived cell hyperactivity in f 1 mice. NZB mice and their F1 hybrids produce excessive polyclonal Ig[immunoglobulin]M and autoantibodies of both IgM and IgG classes. CBA/N mice and CBA/N-mothered F1 males fail to make antibody to many T[thymus]-independent antigens and have low levels...