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The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an x linked bone marrow derived cell defect



The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an x linked bone marrow derived cell defect



Journal of Immunology 119(6): 1874-1878



The primary in vitro antibody response of neonatal spleen cells to 3 thymic independent antigens was examined. The time of onset of responsiveness to TNP[trinitrophenylated]-Brucella abortus and TNP-[Escherichia coli]lipopolysaccharide was significantly earlier than the onset of responsiveness to TNP-Ficoll. This ontologic sequence was not affected by T [thymus-derived] cell depletion or antigen presentation on adult macrophages. In neonatal mice bearing the X-linked CBA/N defect, the response to TNP-B. abortus and TNP-lipopolysaccharide was much delayed and no response to TNP-Ficoll developed. Different thymic independent antigens address different subpopulations of B [bone marrow-derived] cells, one of which appears earlier in ontogeny than the other.

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Accession: 006728342

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