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The opiate receptor and opioid peptides

, : The opiate receptor and opioid peptides. Journal of Neurochemistry 28(1): 13-20

The present knowledge about the opiate receptor and opioid peptides was reviewed. The opiate receptor is sculpted for a normally occurring morphine-like peptide, enkephalin, a neurotransmitter or neuromodulator of neuronal pathways in the brain that may mediate pain perception among other functions. The opiate receptor and other neurotransmitter receptors display several similarities such as differential modes of binding for agonists and antagonists, and selective influences of ions on binding which may relate to ionic mechanisms in synaptic transmission. Studies on rats and other animals were discussed.

Accession: 006728469

PMID: 188984

DOI: 10.1111/j.1471-4159.1977.tb07703.x

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Von Zastrow, M.; Keith, D.E.; Evans, C.J., 1993: Agonist-induced state of the delta-opioid receptor that discriminates between opioid peptides and opiate alkaloids. We report a novel agonist-induced change in delta-opioid receptor binding properties in NG108-15 cells. Pretreatment of these cells with opioid agonists substantially diminishes the binding of peptide agonists and a peptide antagonist to opioid re...

Evans C.J.; Von Zastrow M., 1990: A state of the delta opioid receptor that is blind to opioid peptides yet retains high affinity for the opiate alkaloids. Van Ree, J M , Et Al (Ed ) International Congress Series, No 914 New Leads in Opioid Research; International Narcotics Research Conference, Noordwijkerhout, Netherlands, July 8-13, Xxvii+391p Elsevier Science Publishers B V (Biomedical Division): Amsterdam, Netherlands; (Dist in The Usa And Canada By Elsevier Science Publishing Co , Inc : New York, New York) Illus 159-161

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