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The pharmacokinetics of benzo a pyrene in the isolated perfused rabbit lung the influence of benzo a pyrene n dodecane particulate or sulfur dioxide



The pharmacokinetics of benzo a pyrene in the isolated perfused rabbit lung the influence of benzo a pyrene n dodecane particulate or sulfur dioxide



Toxicology 33(3-4): 275-290



The pharmacokinetics of benzo[a]pyrene (BaP) in the isolated perfused rabbit lung (IPL) following pretreatment of the whole animal or simultaneous administration to the IPL with n-dodecane, ferric oxide, crude airborne particulate (CAP), fly ash or SO2 were investigated using a 1-compartment model. The rate constrant for the appearance (ka) of BaP in the blood, the clearance of BaP from the blood and the rate of appearance of BaP metabolites (RAM) were the kinetic parameters determined. BaP entered the blood rapidly with an average half-life of 11 min experiments in which the IPL received only BaP on perfusion. The logarithms of the clearances from these experiments were linearly correlated with the RAM. Pretreatment of the whole animal with BAP produced a 48-55-fold increase in BaP clearance while pretreatment with n-dodecane increased the clearance 4-fold in comparison with controls. Pretreatment with ferric oxide or ferric oxide and BaP increased the clearance by factors of 5.5- and 1.5-fold, respectively, over those of control and BaP pretreated experiments.

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Accession: 006733935

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DOI: 10.1016/0300-483x(84)90044-1


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