+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The pressor and metabolic effects of alcohol in normotensive subjects

, : The pressor and metabolic effects of alcohol in normotensive subjects. Hypertension 8(7): 625-631

Changes in blood pressure, pulse rate, and plasma catecholamines, renin activity, cortisol, and calcium were studied in 16 normotensive subjects (eight with a family history of hypertension) for 5 hours following ingestion of alcohol-free and alcohol-loaded beer. Both systolic and diastolic blood pressure rose after alcohol consumption; maximum responses occurred at peak blood alcohol concentrations and were significantly higher than those seen after placebo. Pulse rate was also significantly higher after alcohol ingestion and continued to rise throughout the study. There was no difference in the pressor response to alcohol between the groups with and without a family history of hypertension. No difference was found in plasma norepinephrine or epinephrine levels between alcohol and placebo phases. However, subjects with no family history of hypertension had significantly higher plasma norepinephrine levels (p less than 0.01) than did those with a family history during both the alcohol and placebo phases, although baseline blood pressures were not significantly different. Plasma epinephrine level was similar in both groups. Plasma renin activity was unchanged throughout, but plasma cortisol fell during both phases. Plasma calcium showed a small but significant fall with alcohol consumption in both groups (p less than 0.001). These results indicate that in normotensive subjects alcohol ingestion causes a rise in systolic and diastolic blood pressure that is not influenced by a family history of hypertension. This effect does not appear to be sympathetically mediated but may be due to a direct vasoconstrictor effect of alcohol, possibly with an alcohol-induced shift in intracellular calcium.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006740042

PMID: 3522422

DOI: 10.1161/01.HYP.8.7.625

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Nsimba, S.E.D.; Massele, A.Y.; Makonomalonja, J., 2004: Assessing prescribing practice in church-owned primary healthcare (PHC) institutions in Tanzania: a pilot study. 10 church-owned primary healthcare (PHC) institutions in Dar es Salaam, Tanzania, were retrospectively surveyed by trained research assistants to assess the prescribing practices of healthcare providers in these institutions. From a total of 15 00...

Dai, Haibin; Zhang, Zhongmiao; Zhu, Yongpin; Shen, Yao; Hu, Weiwei; Huang, Yuwen; Luo, Jianhong; Timmerman, Henk; Leurs, Rob; Chen, Zhong, 2006: Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H-2 receptor/cyclic AMP/protein kinase A and H-3 receptor/GABA release pathways. Using histamine and the H-3 receptor antagonist thioperamide, the roles of histamine receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons. Within 3 h of intense NMDA insult, most neurons died by necrosis. Histamine...

Nance, Martha A.; Westphal, Beryl, 1996: Diagnosis of patients presenting to a Huntingtons disease clinic without a family history of Huntingtons disease. Neurology 46(2 SUPPL ): A251

Franco Uribe, Alberto, 1947: Characteristics and relationships of soils from volcanic tuffaceous materials in Colombia, South America. The soils of the upper Magda-lena Valley, in a dry tropical hot climate, are Tertiary deposits. They consist of volcanic dust that has been reworked by water and has become hard and indurated. The alluvial plains consist of high and low benches. S...

Snyder, F. M., 1949: Notes and descriptions of some Phaoniinae (Diptera, Muscidae). American Museum Novitates, no. 1402: 25

Zeinert, Karen, 1983: Husbandry of chinchillas. Veterinary Medicine and Small Animal Clinician 78: 92-4

Owen, E.; Bishop, K.; Speakman, C., 1999: The Northern Snowdonia Study - an innovative approach to sustainable tourism development. A study commissioned to consider the potential for an innovate sustainable development initiative that would make visitors to Snowdonia, UK, less dependent on the private motor car is described. In addition, the study sought to generate greater ec...

Pierantoni, Umberto., 1911: Origine e struttura del corpo ovale del Dactylopius cifri e del corpo verde del-l'Aphis brassicae. Seconda nota prel. sulla simbiosi ereditaria. Bollettino della Societa dei Naturalisti in Napoli, 24(1910): 1-4

Lemly, A.Dennis.; Skorupa, J.P., 2007: Technical issues affecting the implementation of US Environmental Protection Agency's proposed fish tissue-based aquatic criterion for selenium. The US Environmental Protection Agency is developing a national water quality criterion for selenium that is based on concentrations of the element in fish tissue. Although this approach offers advantages over the current water-based regulations,...

Tuttle Michele L.; Briggs Paul H.; Evans William C.; Kling George W.; Lockwood John P., 1992: Influence of mafic minerals on water chemistry and water-column stability of Lake Nyos, Cameroon. Proceedings - International Symposium on Water-Rock Interaction 7: 449-452