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The pressor effect of droperidol on a patient with pheo chromo cytoma


, : The pressor effect of droperidol on a patient with pheo chromo cytoma. Anesthesiology (Hagerstown) 46(5): 359-361

Although it was recommended to give phenoxybenzamine orally at the rate of 1 mg/kg per day, it was administered i.v. because prompt and reliable action was necessary when a hypertensive episode was encountered following the trial administration of droperidol. Initially, a dose of 30 mg was given. This was subsequently adjusted to the minimum amount necessary to maintain the desired blood pressure. The small dose used, 0.3 mg/kg/day, caused no side effect and was sufficient to prevent extreme hypertension during the surgical procedure. Although mild hypertension was inevitable, it was easily controlled with phentolamine. The present case made it evident that droperidol causes extreme hypertension in patients with pheochromocytoma. The site of action of droperidol is unknown. In spite of the known pressor effect of the drug in this patient, neuroleptanesthesia using droperidol was applied for the following reasons: The increase in blood pressure induced by droperidol was controllable with an .alpha.-adrenergic receptor blocker. Neuroleptanesthesia does not sensitize the heart to catecholamines as the other halogenated volatile anesthetics. It has little depressant effect on cardiac and renal functions.

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Accession: 006740043

PMID: 851247

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Related references

Webb, T.A.; Sheps, S.G.; Carney, J.A., 1980: Differences between sporadic pheo chromo cytoma and pheo chromo cytoma in multiple endocrine neoplasia type 2. The gross and microscopic pathology of the adrenal gland was studied in 69 [human] cases of sporadic pheochromocytoma to develop a profile of the neoplasm to compare with that of pheochromocytoma observed in the syndrome of multiple endocrine neop...

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