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The pressure resistance relationships of regional resistances within the coronary circulation and the steal phenomenon

Basic Research in Cardiology 73(6): 607-617
The pressure resistance relationships of regional resistances within the coronary circulation and the steal phenomenon
The descending branch of the left coronary artery was ligated in narcotized dogs and the peripheral vascular bed embolized with microspheres. A maximal pharmacological dilatation was induced with carbocromen and dipyridamole and the pressure flow relation of the regional resistances within the coronary circulation was investigated. An increase in the aortic pressure from 100-120 mm Hg decreased the total resistance of the circumflex branch by 6%, but the precollateral resistance which represents chiefly the resistance of large coronary vessels increased by 8%. A decrease with increasing pressure was also shown by the nutritive resistance (chiefly resistance of small vessels and arterioles) and the collateral resistance (resistance of spontaneous collaterals). An increase in perfusion pressure from 70 to 90 mm Hg diminished the nutritive resistance by 13% and the collateral resistance by 17%. During an increase in aortic pressure collateral flow decreased if the relationship precollateral resistance/postcollateral resistance (R1/R4) and collateral resistance/nutritive resistance R3/R2 both increased. Collateral flow increased when the quotients R1/R4 and R3/R2 remained unchanged or decreased when aortic pressure was enhanced. Apparently not every increase in aortic pressure leads to an increase in collateral flow. A decrease in collateral flow which can produce the steal phenomenon can also develop following an increase in aortic pressure in as much as the regional resistances which influence collateral flow are changed correspondingly.

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Accession: 006740070

PMID: 747619

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