+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The prethcamide hydroxylation system in rat hepatic microsomes

, : The prethcamide hydroxylation system in rat hepatic microsomes. Acta Biochimica Polonica 31(4): 409-420

Ethyl butamide and propyl butamide, the active constituents of the analeptic drug named Prethcamide (Ciba-Geigy), undergo biotransformation to respective single metabolites in the presence of rat hepatic microsomes and the NADPH-generating system. Spectral analysis showed that the metabolites were hydroxylated forms of the drug. The hydroxylation was stimulated by NADH and increased ionic strength, and inhibited by the known cytochrome P-450 inhibitors, e.g. SKF-525A [2-(diethylamino)ethyl-2,2-diphenylvalerate hydrochloride], metyrapone, CO and KCN. The drug formed type I binding spectrum with cytochrome P-450.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006740120

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Nosaka, Chisato; Kunimoto, Setsuko; Atsumi, Sonoko; Takeuchi, Tomio, 1999: Inhibition of nitric oxide synthase induction by 15-deoxyspergualin in a cultured macrophage cell line, J744A.1 activated with IFN-gamma and LPS. Immunosuppressant 15-deoxyspergualin (DSG) inhibited induction of inducible nitric oxide synthase (iNOS) following stimulation with IFN-gamma and LPS in a cultured macrophage cell line, J744A.1. By DSG treatment NO2- accumulation in the medium was...

Galvez G.E.; Castano M.; Vesga B.; Kitajima E.W., 1976: Purification and serology of the necrotic streak mosaic virus of sisal. Proceedings of the American Phytopathological Society 3: (1977)

Aksenov V.M., 1970: Parallel study of the character of micro flora of tonsillar lacunae titers of streptococcal antibodies and results of the intra dermal tests with bacterial allergens in patients with chronic tonsillitis. Vestnik Otorinolaringologii 32(3): 64-69

Boyer, C. B.; Barrett, D. C.; Peterman, T. A.; Bolan, G., 1997: Sexually transmitted disease (STD) and HIV risk in heterosexual adults attending a public STD clinic: evaluation of a randomized controlled behavioral risk-reduction intervention trial. In San Francisco a total of 399 STD patients were randomly assigned to a four-session, individual, multi-component, cognitive/behavioural intervention (n = 199), or a brief standardized counselling session offered to all patients (n = 200). There...

Fasciolo, J. C.; Taquini, A. C., 1947: Metodo para el reconocimiento de pequenas cantidades de renina. Renin in blood can be estimated by first incubating plasma free of hypertensinase with hypertensinogen for 3 hrs, at 37[degree]C. The amt. of hypertensin thus formed is estimated by its vasoconstrictor action of the vascular bed of toad legs with...

Shiomi K.; Matsuzaki M.; Ozaki M.; Murata K.; Kohno M.; Katayama K.; Fujii T.; Tanaka N.; Sakai H.; Et Al, 1990: Analysis of intravascular pulmonary fluid distribution during pulmonary congestion by digital subtraction angiography. Japanese Circulation Journal 54(7): 811-812

Gao, Ben Bo; Han, Qi De, 1998: No functional beta3-adrenergic receptors expressed in rat skeletal muscle cells. AIM: To determine the functional role of beta3-adrenoceptors (beta3-AR) in rat skeletal muscle cells. METHODS: Nonselective beta-AR agonist isoprenaline (isoproterenol, Iso), beta3-AR agonist CGP12177A which is a beta1-/beta2-AR antagonist and sel...

Bultot F.; Coppens A.; Dupriez G.L.; Gellens D.; Meulenberghs F., 1988: Repercussions of a carbon dioxide doubling on the water cycle and on the water balance a case study for belgium. The impact of the climate change induced by a doubling of the CO2 atmospheric concentration on the hydrologic system is investigated. For this purpose, a daily step conceptual hydrological model (developed at the Royal Meterorological Institute of...

Guilliermond, A., 1941: Donnees actuelles sur la signification physiologique des chondriosomes. This is a critical review of literature dealing with the functions of mitochondria.

Duun, E. H.; Norgaard, K.; Deckert, T.; Binder, V., 1995: Prevalence of gastrointestinal symptoms in IDDM. Diabetologia 38(SUPPL 1): A244