EurekaMag.com logo
+ Translate

The prevalence and possible significance of immuno globulin d granulocyte specific anti nuclear antibodies in neutropenic and nonneutropenic cases of rheumatoid arthritis


, : The prevalence and possible significance of immuno globulin d granulocyte specific anti nuclear antibodies in neutropenic and nonneutropenic cases of rheumatoid arthritis. Acta Pathologica et Microbiologica Scandinavica Section C Immunology 86(1): 19-22

Sera from 21 rheumatoid arthritis [RA] patients with accompanying neutropenia (.ltoreq. 2000 neutrophils/.mu.l) and 45 RA patients without neutropenia were studied for the occurrence of Ig[immunoglobulin]D granulocyte-specific antinuclear antibodies. Such antibodies were found in 67% of the neutropenic and 18% of the non-neutropenic cases (P < 0.001). The titers of IgD granulocyte-specific antinuclear antibodies varied independently of the titers of IgD and complement-fixing granulocyte-specific antinuclear antibodies, but showed some covariation with granulocyte-specific antinuclear antibodies of the IgA and IgM classes most probably reflecting a broad polyclonal antibody response to phagocyte nuclear antigens in the serologically highly active neutropenic cases. Gel filtration studies on selected sera containing IgD granulocyte-specific antinuclear antibodies indicated participation of these antibodies in immune complexes. IgD granulocyte-specific antinuclear antibodies may have some significance for the rheumatoid inflammatory processes.

(PDF 0-2 workdays service)

Accession: 006740166

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Wiik, A.; Permin, H., 1978: The prevalence and possible significance of IgD granulocyte-specific antinuclear antibodies in neutropenic and non-neutropenic cases of rheumatoid arthritis. Sera from 21 rheumatoid arthritis patients with accompanying neutropenia (less than or equal to 2000 neutrophils/microliter) and 45 rheumatoid arthritis patients without neutropenia were studied for the occurrence of IgD granulocyte-specific antin...

Wiik A., 1975: Immune complexes in rheumatoid arthritis sera and synovial fluids containing immuno globulin g granulocyte specific anti nuclear factors but not immuno globulin g heterophilic antibodies to rabbit red cells. Scandinavian Journal of Rheumatology 4(3): 116

Permin, H.; Wiik, A., 1978: The prevalence of immuno globulin e anti nuclear antibodies in rheumatoid arthritis and systemic lupus erythematosus. Antinuclear antibodies (ANA) of the Ig[immunoglobulin] class were studied in sera from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and healthy controls. Of 20 RA patients with neutropenia, 60% had IgE granulocyte-sp...

Wiik A.; Henriksen K.; Faber V., 1975: Urinary excretion of granulocyte specific anti nuclear factors in rheumatoid arthritis predominance in neutropenic cases showing high titers of complement fixation. Acta Pathologica et Microbiologica Scandinavica Section C Immunology 83(4): 273-279

Shirodaria P.V.; Fraser K.B.; Armstrong M.; Roberts S.D., 1979: Measles virus specific antibodies and immuno globulin m anti globulin in sera from multiple sclerosis and rheumatoid arthritis patient. When rheumatoid factor in rheumatoid arthritis and multiple sclerosis sera was titrated by the fluorescent antibody [Ab] method on measles virus-infected cells, there was a marked and variable drop in titer on acetone-fixed cells as compared with...

Chellingworth M.C.; Salmon M.; Scott D.L.; Bacon P.A., 1984: The significance of immuno globulin m anti nuclear antibody in rheumatoid arthritis and other connective tissue diseases. An investigation of the incidence of IgG and antinuclear antibodies (ANA) in patients with connective tissue diseases showed that IgM ANA predominated in rheumatoid arthritis, while in systemic lupus erythematosus IgG antibodies were more common....

Scott Morgan L.; Lloyd R.S., 1980: Failure to demonstrate any interaction between poly clonal rheumatoid factors and immuno globulin g anti nuclear antibodies or other immuno globulin auto antibodies. The autoantibody profile results from 750 randomly selected patients with rheumatoid factor (RF) and/or antinuclear antibody (ANA) positive tests were retrospectively analyzed in order to discover if the presence of polyclonal rheumatoid factors a...

Ritchie R.F., 1968: Immuno globulin d anti nuclear antibodies abstract human rat liver sera systemic lupus erythematosis rheumatoid arthritis. Arthritis & Rheumatism 11(3): 506

Permin H.; Egeskjold E M., 1982: Immuno globulin e anti immuno globulin g antibodies on patients with juvenile and adult rheumatoid arthritis including feltys syndrome. Anti-IgG antibodies (anti-IgG) of the IgE class were studied in sera from patients with juvenile rheumatoid arthritis (JRA), rheumatoid arthritis (RA) and patients with Felty's syndrome (FS) by use of an indirect immunofluorescence technique....

Heimer, R.; Wolfe, L.D.; Abruzzo, J.L., 1982: Immuno globulin m and immuno globulin g anti fab' 2 antibodies in rheumatoid arthritis and systemic lupus erythematosus. Radioimmunoassays for anti-F(ab')2 antibodies, which feature the use of goat anti-human Fc antibody for correcting potentiation of IgM anti-F(ab')2 antibody titers by endogenous IgM anti-Fc antibodies (rheumatoid factors), are described....