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The prevalence of antibodies to reovirus type 3 in adults with idiopathic cholestatic liver disease


, : The prevalence of antibodies to reovirus type 3 in adults with idiopathic cholestatic liver disease. Journal of Medical Virology 16(1): 55-60

Sera from 22 adults with idiopathic cholestatic liver disease (16 primary biliary cirrhosis and six primary sclerosing cholangitis) were tested for antibody to Reovirus type 3 (Reo-3) virus by a standard hemagglutination inhibition assay. The results were compared to antibody prevalence in 10 adults with various other causes of chronic liver disease and 11 healthy volunteers. Although patients with idiopathic cholestatic liver disease had a high prevalence of anti Reo-3 antibodies (20/22. 91%), similar prevalence rates were found in the 2 control populations (7/10, 70% in chronic liver disease controls and 11/11, 10% in healthy volunteers). The geometric mean titers of antibody to Reo-3 virus were similar in all study groups. While the results do not exclude a pathogenetic role for Reo-3 viral infection, they do imply that some genetic predisposition must exist if Reo-3 infection is truly of pathogenetic importance in idiopathic cholestatic liverdisease of adults.

Accession: 006740219

PMID: 2995568

DOI: 10.1002/jmv.1890160108

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