EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

The prevalence of congenital abnormalities in patients with positive contraction stress tests


, : The prevalence of congenital abnormalities in patients with positive contraction stress tests. Journal of Perinatal Medicine 15(3): 291-296

Over a period of 10 years, 60 197 stress and nonstress tests were done in 25 313 patients. There were 229 (0.9%) positive tests. In 47.2% of patients who had positive tests, preeclampsia and hypertension were the indications for the test followed by suspected intrauterine growth retardation (26.6%) (table I). The cesarean section incidence was 71%. The mean age of the patients was 32 years. Nine per cent of patients were 45 years or older. 7% between 40 and 44 years, 23% between 35 and 39 years, 30% between 30 and 34 years. 20% between 25 and 29 years, 7% between 20 and 24 years and 4% younger than 20 years. There were 13 intrauterine deaths of which 9 fetuses were regarded as too small to be delivered. Of the remaining 4 patients, intrauterine death occurred in 3 patients before cesarean section could be done and in the fourth a macerated twin was unexpectantly found when a cesarean section was done for fetal distress. Routine autopsies were not done on intrauterine deaths. The only external abnormality that could be found was an umbilical hernia. Apart from this abnormality there were 9 liveborn babies with congenital abnormalities. Four of these babies died neonatally, bringing the perinatal death rate up to 50%. Four babies (1.7%) had chromosomal abnormalities. These were trisomy-21 in two patients, a trisomy-18 and a true hermaphrodite. Ages of the patients with the trisomy-21 were 46 and 49 years. Other abnormalities were exomphalos, microcephalus with hypospadia, hydrocele, polysyndactyly and hypospadia. One newborn had several congenital abnormalities including mitral valve atresia, malrotation of the colon, absence of one umbilical artery, a horse-shoe kidney and arrhenin-encephaly. Although the incidence of chromosomal abnormalities was much higher than the general incidence in an obstetric population, it is probably due to the high maternal age in the study (38% of patients were 35 years or older). They were probably selected because of their hypertension. As most of the babies who died neonatally were delivered by cesarean section one would have liked to make the diagnosis of the lethal congenital abnormality antenatally. However, antenatal diagnosis probably was only possible in the patients with the microcephaly and with the trisomy-18. Proper antenatal screening for trisomy-21 in the older patient should eliminate the problem of trisomy-21.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006740286

PMID: 3430326

DOI: 10.1515/jpme.1987.15.3.291

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Leartsakulpanich, U.; Antonkine, M.L.; Ferry, J.G., 2000: Site-specific mutational analysis of a novel cysteine motif proposed to ligate the 4Fe-4S cluster in the iron-sulfur flavoprotein of the thermophilic methanoarchaeon Methanosarcina thermophila. Isf (iron-sulfur flavoprotein) from Methanosarcina thermophila has been produced in Escherichia coli as a dimer containing two 4Fe-4S clusters and two FMN (flavin mononucleotide) cofactors. The deduced sequence of Isf contains six cysteines (Cys 1...

Rathod, Pradipsinh K.; Khatri, Ashok, 1990: Synthesis and antiproliferative activity of threo-5-fluoro- L-dihydroorotate. The Journal of Biological Chemistry 265: 242-9

Caballero, J. M.; Esteve, M. A.; Calvo, J. F., 2002: Description of halophytic plant communities: comparing vegetation groups obtained by multivariate analysis and syntaxa. Six vegetation groups (A-F) had been defined in the salt steppes of the Guadalentin (Murcia, Spain) by means of multivariate methods. Each of them is characterized by the dominance of certain halophytic or sub-halophytic species. In the present pa...

Toraason M.; Breitenstein M., 1988: Prenatal ethylene glycol monomethyl ether egme exposure produces electrocardiographic changes in the rat. The purpose of the present study was to determine if electrocardiographic (EKG) changes observed in fetuses exposed in utero to ethylene glycol monomethyl ether (EGME) persisted beyond the fetal/neonatal period. Groups of pregnant Sprague-Dawley r...

Sener, Göksel.; Paskaloglu, Kübra.; Toklu, H.; Kapucu, C.; Ayanoglu-Dulger, G.; Kacmaz, A.; Sakarcan, A., 2004: Melatonin ameliorates chronic renal failure-induced oxidative organ damage in rats. Chronic renal failure (CRF) is associated with oxidative stress that promotes production of reactive oxygen species (ROS). Melatonin, the chief secretory product of the pineal gland, was recently found to be a potent free radical scavenger and ant...

Levison, S. W.; Abramson, B. J.; Goldman, J. E., 1992: A common progenitor for type 1 and type 2 astrocytes exists in newborn rat subventricular zone. Society for Neuroscience Abstracts 18(1-2): 30

Owen Edgar W., 1964: Petroleum in carbonate rocks. The stratigraphic and structural habitats of many oil and gas pools in carbonate rocks indicate indigenous origin of their hydrocarbons.

Santisteban G.A.; Ely J.T.A.; Read D.H.; Hamel E.; Rowin M.E., 1985: Glycemic modulation of leukocytic function. Anatomical Record 211(3): 167A-168A

Prescott, H. W., 1955: Neorhynchocephalus sackenii and Trichopsidea clausa nemestrinid parasites of grasshoppers. Annals of the Entomological Society of America 48(5): 392-402

Rius, Marc; Mcquaid, Christopher D., 2006: Wave action and competitive interaction between the invasive mussel Mytilus galloprovincialis and the indigenous Perna perna in South Africa. On the south coast of South Africa, the invasive alien mussel Mytilus galloprovincialis shows partial habitat segregation with the indigenous mussel Perna perna. P. perna predominates in the lower mussel zone and M. galloprovincialis in the upper...