EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The prevalence of hepatitis B surface antigen in commercially prepared plasma products


Journal of Laboratory and Clinical Medicine 88(1): 102-113
The prevalence of hepatitis B surface antigen in commercially prepared plasma products
Commercially available lots of plasma derivatives prepared between 1957 and 1975 were tested for hepatitis B surface antigen (HBsAg) by radioimmunoassay. In all, 69 per cent of lots of plasma protein fraction, 40 per cent of factor IX concentrate, 20 per cent of normal serum albumin, 13 per cent of antihemophilic factor, 3 per cent of fibrinogen, and 0.7 per cent of immune serum globulin lots tested were HBsAg-positive. There was great variation in the prevalence of HBsAg-positive lots of each product among the different manufacturers, reflecting not only differences in methods of processing plasma, but also differences in donor populations. Those manufacturers relying upon volunteer donor plasma or placental source material demonstrated lower rates of HBsAg-positive lots of final products than those relying upon commercial donor plasma. There was a marked decrease in the prevalence of positive lots during the period 1971 to 1973, coincident with the onset of routine plasma donor screening for HBsAg. However, current requirements for plasma screening have not resulted in totally HBsAg-free plasma products. Use of more sensitive and more reliable tests for HBsAg will probably reduce contamination of plasma pools with HBsAg to undetectable levels. Despite HBsAg-status, however, the "high-risk" plasma products (fibrinogen, antihemophilic factor, factor IX concentrate) must still be considered capable of transmitting hepatitis and used only with the strictest indications.


Accession: 006740369

PMID: 932529



Related references

Evaluation of screening for hepatitis B surface antigen during pregnancy in a population with a high prevalence of hepatitis B surface antigen-positive/hepatitis B surface antigen-negative carriers. Pediatric Infectious Disease Journal 18(3): 262-266, March, 1999

Evaluation of screening for hepatitis B surface antigen during pregnancy in a population with a high prevalence of hepatitis B surface antigen-positive/hepatitis B e antigen-negative carriers. Pediatric Infectious Disease Journal 18(3): 262-266, 1999

Investigations on hepatitis b e antigen 1. prevalence of hepatitis b e antigen and anti hepatitis b e antibody in the stationary phase of hepatitis b surface antigen positive acute viral hepatitis. Revue Roumaine de Medecine Virologie 32(2): 93-98, 1981

Correlation of the e antigen antibody system with intra hepato cellular hepatitis b core antigen and hepatitis b surface antigen in hepatitis b surface antigen positive acute and chronic liver diseases and healthy hepatitis b surface antigen carriers. Digestion 14(5/6): 488, 1976

Effect of transfusion of fresh-frozen plasma on recipients' antibodies to hepatitis B surface antigen and hepatitis B surface antigen status in countries where hepatitis B virus is endemic. Vox Sanguinis 83(3): 209-213, October, 2002

Effect of transfusion of fresh-frozen plasma on recipients' antibodies to hepatitis B surface antigen and hepatitis B surface antigen status in countries where hepatitis B virus is endemic. Vox Sanguinis 83(3): 209-213, 2002

Immunologic studies on hepatitis b surface antigen part 1 hepatitis b surface antigenemia and anti hepatitis b surface antigen after the hepatitis b surface antigen transfusion antigen positive blood preserves. Zentralblatt Fuer Bakteriologie Parasitenkunde Infektionskrankheiten Und Hygiene Erste Abteilung Originale Reihe A Medizinische Mikrobiologie Und Parasitologie-3: 295-297, 1976

Prevalence of hepatitis b e antigen antibody to hepatitis b e antigen and dane particle associated dna polymerase activity in asymptomatic carriers of hepatitis b surface antigen. Ricerca in Clinica e in Laboratorio 9(1): 35-40, 1979

Age specific prevalence of hepatitis b e antigen and antibody to hepatitis b e antigen among asymptomatic hepatitis b surface antigen carriers in okinawa and kyushu japan. Microbiology & Immunology 30(7): 675-682, 1986

Immuno globulin m immuno globulin g antibody to hepatitis b core antigen implications from its prevalence in hepatitis b surface antigen carriers and hepatitis b surface antigen negative chronic hepatitis. Gastroenterology 79(5 PART 2): 1124, 1980