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The prevention and therapy by simian liver extract and bovine gallbladder bile against herpes simplex virus infected mice

, : The prevention and therapy by simian liver extract and bovine gallbladder bile against herpes simplex virus infected mice. Journal of the Kurume Medical Association 48(6): 443-448

It has been previously reported that liver extract and bile from various animals inhibit the growth or inactivate the infectivity of herpes simplex virus. The present studies were done, in vivo, to examine these preventions of illness and therapy against various viral infections. Five weeks old BALB/c mice died by intraperitoneal inoculation with viruses of 4.3 .times. 105 PFU in 0.5 ml. No virus could be recovered from heart, lung or genital organ of the 44 mice died. Viruses with very low titers were recovered in one case from kidney, 4 from liver, and 24 from brain. No virus neutralizing or inactivating substances were contained in extracts from various organs two months after inoculation. It was ascertained that 1% of liver extract and 0.1% of bile had the preventing and therapeutic effects against inoculation with UW-268 virus of 4.3 .times. 106 PFU in 0.5 ml. Although an addition of 1% liver extract to the cells infected with herpes simplex virus inhibited the appearance of CPE as well as virus growth, its removal caused the appearance of CPE and high yield of virus. Therefore, this experimental system would be used as a good model to approach the mechanisms pertaining to inhibition of virus growth and also to latent infection of herpes simplex virus.

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