EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The prevention of acetaminophen induced hepato toxicity by the interferon inducer poly ribo inosinic acid ribo cytidylic acid


, : The prevention of acetaminophen induced hepato toxicity by the interferon inducer poly ribo inosinic acid ribo cytidylic acid. Toxicology & Applied Pharmacology 72(1): 40-45

When mice were pretreated with the interferon inducer poly(rI .cntdot. rC) for 24 h, the mortality caused by acetaminophen was significantly reduced. Acetaminophen doses up to 600 mg/kg which killed 100% of the saline-treated control mice caused no deaths in poly(rI .cntdot. rC)-treated animals. Even doses as high as 900 mg/kg acetaminophen killed only 38% of the animals. Histological examination of the livers demonstrated that acetaminophen-induced necrosis was decreased in poly(rI .cntdot. rC)-treated animals compared to controls. Significant protection against necrosis was observed even with doses as high as 900 mg/kg acetaminophen. Following a dose of 300 mg acetaminophen, 0.67 .+-. 0.5 nmol/mg protein were covalently bound to liver protein in control mice compared to 0.33 .+-. 0.02 nmol/mg protein bound in poly(rI .cntdot. rC)-treated mice. This protective effect of poly(rI .cntdot. rC) did not result from an increase in hepatic glutathione content; in fact, the glutathione level was depressed in animals treated with poly(rI .cntdot. rC). Since cytochrome P-450 levels were depressed in these experiments, it is concluded that poly(rI .cntdot. rC) depresses the cytochrome P-450 species responsible for the formation of the toxic metabolite and less reactive species are available for binding to cell macromolecules. The toxicity of acetaminophen may be decreased considerably during viral infections which promote the formation of interferon. [Implications with respect to the effects of this drug in man are presented.].

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006740583

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Rolle, J., 1916: Die Bedingungen fur das Gedeihen der Scidenzucht und deren volkswirtschaftliche Bedeutung. Zeitschrift fuer Angewandte Entomologie, 3 210-256

Kohn, R.; Novak, M.; Melichar, V.; Havlova, M.; Vinsova, N., 1961: Changes in cholesterolaemia and serum phospholipids in the neonatal period with changes in nutrition.. Newborn infants, breast-fed from birth, showed a continual increase in blood serum cholesterol and phospholipid levels, while infants given only 10% glucose solution during the first 3 days of life showed a slight increase in serum cholesterol and...

Makris John P.; Savvaidis Alexandros S.; Vallianatos Filippos, 2002: MT-data analysis from a survey in the Mygdonia Basin (N. Greece). A magnetotelluric (MT) profile comprising eight measuring sites was conducted in the Mygdonia basin, a European Seismological Test Site. The MT-stations were deployed in a direction almost perpendicular to the major axis of the sedimentary basin t...

Muraoka, Masami; Morishita, Koji; Aida, Nagisa; Tanaka, Masashi; Yuri, Masatoshi; Ohashi, Naohito, 2002: Pyridone derivatives and process for preparing the same. A process for preparing a pyridone derivative (4), which comprises reacting the compound (1) with a hypochlorite or a hypobromite or with lead tetraacetate to give the compound (2), and reacting the compound (2) with the compound (3). Said process...

Frick, J., 1976: Orientation and behaviour of hatchling green turtles (Chelonia mydas) in the sea. Animal Behav, 244: 849-857

Titze, I. R., 1976: On the mechanics of vocal fold vibration. The human vocal fold was treated as a continuous, transversally isotropic, bounded medium. The theory of viscoelasticity was applied to formulate the stresses, strains, glottal tissue impedance and propagation characteristics for sinusoidal oscill...

Fontenot, Andrew, P.; Edwards, David, M.; Chou, Yuan, K.; Mack, Douglas, G.; Latocha, Dorian; Vandenbark, Arthur, A.; Burrows, Gregory, G., 2006: Self-presentation of beryllium by BAL CD4(+) T cells: T cell-T cell interactions and their potential role in chronic beryllium disease. Chronic beryllium disease (CBD) is characterized pathologically by granulomatous inflammation in the lung, composed of a large core of epithelioid cells surrounded by a dense shell of CD4(+) T cells. Using beryllium-specific CD4(+) T cell lines de...

Kristensen, Bjarne W.; Noraberg, Jens; Zimmer, Jens, 2001: Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures. The excitotoxic profiles of (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propionic acid (ATPA), (RS)-2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainic acid (KA) and N-methyl-D-aspartate (NMDA) were evaluated using cellula...

Troy, J. B.; Lennie, P., 1987: Detection latencies of x and y type cells of the cat's dorsal lateral geniculate nucleus. The latencies of visually-evoked responses from X- and Y-type neurons of the cat's dorsal lateral geniculate nucleus were measured in a manner that takes account of the inherent variability of discharge in these cells. Latencies measured in t...

Shields, R., 1977: Laboratory maintenance of a marine parasitic copepod. Wiadomosci Parazytologiczne, 231-3: 189-193