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The prevention of alcoholic fatty liver using dietary supplements di hydroxy acetone pyruvate and riboflavine compared to arachidonic acid in pair fed rats

, : The prevention of alcoholic fatty liver using dietary supplements di hydroxy acetone pyruvate and riboflavine compared to arachidonic acid in pair fed rats. Lipids 16(1): 43-51

Male Sprague-Dawley rats were fed for 30 days a high-fat liquid ethanol diet with dihydroxyacetone, pyruvate and riboflavine added as supplements (AMA). Plasma triglyceride (TG) levels were 6-fold greater in these rats than in those fed and alcohol with or without the supplements (AA). The liver TG content in rats fed the AMA diet was similar to that of rats fed a control diet (CA) in which alcohol was replaced with isocaloric amounts of dextrose. Livers of rats fed the AA diet had 3 times more TG than controls. Alcohol ingestion enhanced the hepatic content of cholesteryl esters (CE) and phospholipids (PL). These lipids were reduced to levels found in livers of rats fed the CA diet when dihydroxyacetone, pyruvate and riboflavine were included in the alcohol diet. The fatty acid compositions of TG, CE and PL from livers of rats fed the AMA diet were similar to those of corresponding lipids from rats fed the CA diet but differed from compositions when fed the AA diet. Regardless of the diet fed, TG had the same fatty acid composition in plasma and liver. The same was true of PL fatty acid composition. However, the fatty acid composition of CE differed between liver and plasma. The major fatty acid in liver CE was 18:1 whereas in plasma it was arachidonic acid (20:4). Reduced fatty liver was observed in an earlier study when rats were fed ad lib an ethanol diet containing 20:4. The same diet was pair-fed and fatty liver was not reduced. Dihydroxyacetone, pyruvate and riboflavine did not prevent alcohol-induced fatty liver when 20:4 was included in the AMA diet. Dietary dihydroxyacetone, pyruvate and riboflavine apparently prevent alcohol-induced fatty liver; this effect may result from increased mobilization of fat from liver.

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