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The prevention of alloxan induced diabetes by amygdalin


, : The prevention of alloxan induced diabetes by amygdalin. Life Sciences 27(8): 659-662

Amygdalin given to male Swiss-Webster mice i.p. at 3g/kg 1 h prior to 75 mg/kg i.v. of alloxan, was able to protect against the diabetogenic actions of alloxan. The protection by amygdal in apparently is due to its scavenging of the deleterious and highly reactive hydroxyl radical which was generated from alloxan. Several other mechanisms of protection are also viable.

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Accession: 006740586

PMID: 7412494

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Related references

Cabbat F.S.; Heikkila R.E., 1980: The prevention of alloxan induced diabetes in mice by amygdalin correlation between reactivity with the hydroxyl radical and protection. Federation Proceedings 39(3): ABSTRACT 1969

Murnane, J.M.; Ritter, S., 1985: Alloxan-induced glucoprivic feeding deficits are blocked by D-glucose and amygdalin. Intracerebroventricular injection of alloxan, a pancreatic beta (B) cell cytotoxin, impairs glucoprivic feeding in rats. The goal of this experiment was to determine whether alloxan-induced impairment of glucoprivic feeding can be attenuated by ag...

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