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The prevention of extra cardiac conduit obstruction

Journal of Surgical Research 34(5): 463-472
The prevention of extra cardiac conduit obstruction
Acquired right ventricular (RV) extracardiac conduit (ECC) obstruction was studied in an animal model. A 16 mm woven Dacron tube graft was inserted between the right ventricle (RV) and main pulmonary artery (PA) in 18 adult mongrel dogs followed by pulmonary artery occlusion with a Dacron tape. In 9 dogs the RV anastomosis was maintained with a 16 mm Dacron covered polypropylene stent. The remaining 9 animals with direct suture attachment of the graft to the myocardium served as controls. Cardiac output and transconduit resistance were measured at operation, 6 mo., and 1 yr. The cardiac output remained the same in both groups. Animals with stented ECC showed little change in transconduit resistance and had a widely patent RV anastomosis at 1 yr. Unstented conduits had increased transconduit resistance at 6 mo. and 1 yr (P < 0.002). Postmortem examination showed fibromuscular ingrowth of the ventricular anastomosis to be the site of the acquired obstruction in unstented extracardiac conduits. The inclusion of a rigid stent in RV-ECC may warrant clinical application to prevent fibromuscular ingrowth and late RV anastomotic obstruction.

Accession: 006740609

PMID: 6221159

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