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The prevention of respiratory distress syndrome in premature infants efficacy of ante natal aminophylline treatment vs. pre natal gluco corticoid administration

, : The prevention of respiratory distress syndrome in premature infants efficacy of ante natal aminophylline treatment vs. pre natal gluco corticoid administration. Pediatric Pharmacology 4(1): 21-24

Antepartum administration of aminophylline (AF) to pregnant animals resulted in accelerated and increased pulmonary maturation as well as in decreased morbidity and mortality from RDS [respiratory distress syndrome] in premature offspring. The effect of antenatal AF treatment was evaluated on the frequency of RDS among premature infants born of women who were treated (18), and this group was compared with betamethasone (GC)-treated group (16 women). No statistical significant differences were noted between the AF and GC groups in the incidence of RDS (AF = 11.0%; GC = 0%) and in the frequency of perinatal deaths (AF and GC = 0%). Only a significant difference was noted between the AF group and the GC group in the incidence of neonatal signs of infection (AF = 0%; GC = 50%). Antenatal AF treatment may be as effective as GC in the prevention of RDS in premature infants with, for the moment, no side effects.

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