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The prevention of respiratory distress syndrome in premature infants efficacy of ante natal aminophylline treatment vs. pre natal gluco corticoid administration


, : The prevention of respiratory distress syndrome in premature infants efficacy of ante natal aminophylline treatment vs. pre natal gluco corticoid administration. Pediatric Pharmacology 4(1): 21-24

Antepartum administration of aminophylline (AF) to pregnant animals resulted in accelerated and increased pulmonary maturation as well as in decreased morbidity and mortality from RDS [respiratory distress syndrome] in premature offspring. The effect of antenatal AF treatment was evaluated on the frequency of RDS among premature infants born of women who were treated (18), and this group was compared with betamethasone (GC)-treated group (16 women). No statistical significant differences were noted between the AF and GC groups in the incidence of RDS (AF = 11.0%; GC = 0%) and in the frequency of perinatal deaths (AF and GC = 0%). Only a significant difference was noted between the AF group and the GC group in the incidence of neonatal signs of infection (AF = 0%; GC = 50%). Antenatal AF treatment may be as effective as GC in the prevention of RDS in premature infants with, for the moment, no side effects.

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Related references

Howie R.N.; Liggins G.C., 1973: Prevention of respiratory distress syndrome in premature infants by ante partum gluco corticoid treatment. Villee, Claude A , Dorothy B Villee And James Zuckerman (Ed ) Respiratory Distress Syndrome Proceedings Of A Conference Dedham, Mass , Usa, May 4-6, Xiii+406p Illus Academic Press: New York, N Y , Usa; London, England 369-380

Granati, B.; Grella, P.V.; Pettenazzo, A.; D.L.nardo, L.; Rubaltelli, F.F., 1984: The prevention of respiratory distress syndrome in premature infants: efficacy of antenatal aminophylline treatment versus prenatal glucocorticoid administration. Antepartum administration of aminophylline (AF) to pregnant animals resulted in accelerated and increased pulmonary maturation as well as in decreased morbidity and mortality from RDS in premature offspring. The present study was undertaken to eva...

López-Suárez, O.; García-Magán, C.; Saborido-Fiaño, R.; Pérez-Muñuzuri, A.; Baña-Souto, A.; Couce-Pico, M.L., 2016: Ante-natal corticosteroids and prevention of respiratory distress in the premature newborn: usefulness of rescue treatment. The effectiveness of antenatal corticosteroid therapy for foetal lung maturation in pre-term infants is well known, but there is uncertainty about the time that the treatment remains effective. A descriptive, longitudinal study was conducted to de...

Luerti M.; Spagnolo D.; Zavattini G.; Bianchi C.; Barbera A.G.; Corbella E., 1984: Cord blood prolactin and thyroid hormone levels after ante natal administration of betamethasone or ambroxol for prevention of respiratory distress syndrome. Ambroxol is efficacious in enhancing fetal lung maturation, provided large doses are given. Cord blood levels of PRI [prolactin] and thyroid hormones were investigated in 31 infants born after antenatal administration of betamethasone, in 31 infan...

Outerbridge, E.W., 1978: Ante natal diagnosis and prevention of respiratory distress syndrome. Antenatal diagnosis of respiratory distress syndrome is suggested by analysis of the lecithin/sphingomyelin ratio in amniotic fluid. Risk of amniocentesis is decreased with location of the fetus by ultrasonography. Respiratory distress syndrome is...

Hadjigeorgiou, E.; Kitsiou, S.; Psaroudakis, A.; Segos, C.; Nicolopoulos, D.; Kaskarelis, D., 1979: Antepartum aminophylline treatment for prevention of the respiratory distress syndrome in premature infants. The frequency of idiopathic respiratory distress (IRD) among premature offspring born of women who were given aminophylline before the thirty-fourth week of pregnancy was evaluated. Sixty-seven premature deliveries were included in the aminophylli...

Waffarn F.; Siassi B.; Schmidt P.; Cabal L.; Hodgman J.E., 1979: The association of ante natal gluco corticoid administration and patent ductus arteriosus in the preterm infant. Pediatric Research 13(4 PART 2): 353

Aldige C., 1978: Pre natal thyroid abnormalities in premature infants with respiratory distress syndrome. Pediatric Researchpart 2: 409

Manniello R.L.; Adams A.J.; Farrell P.M., 1976: Prevention of prolonged neo natal hypo glycemia with ante natal gluco corticoids in rats with intra uterine growth retardation. Pediatric Research 10(4): 413

Cosmi E.V.; Felli F.; Grossmann G.; Lachmann B.; Robertson B., 1979: Improved survival in the premature rabbit neo nate following ante natal treatment with aminophylline. IRCS (International Research Communications System) Medical Science Library Compendium 7(3): 115