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The prevention of rifampicin resistance with pyrazinamide

, : The prevention of rifampicin resistance with pyrazinamide. Revue des Maladies Respiratoires 2(4): 205-208

The capacity of pyrazinamide (PZA) to prevent the selection of rifampicin (RMP) resistant mutants were tested by the intravenous inoculation of 160 mice with 2 .times. 106 c.f.u. [colony forming unit] of Mycobacterium tuberculosis, and two weeks later, the treatment of the mice either with 10 mg/kg/day RMP alone or with RMP + PZA 150 mg/kg/day. After three months of treatment, lungs and spleen were culture positive in respectively 95% and 90% of the mice treated with RMP alone and in 37% and 24% of the mice treated by RMP + PZA (p < 10-5). The strains isolated from lungs and spleen were resistant to rifampicin in respectively 87% and 75% of the mice treated with RMP alone and in none of those treated with RMP + PZA.

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