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The prevention of shock produced by clostridium perfringens toxin following the administration of perfringens antiserum experimental study


, : The prevention of shock produced by clostridium perfringens toxin following the administration of perfringens antiserum experimental study. Revista de Pediatrie Obstetrica si Ginecologie Seria Obstetrica si Ginecologie 32(4): 309-314

Total toxin extract of C. perfringens was administered i.v. to 6 beagle bitches, anesthetized with chloralose, after 15 min previous injection of 1000 U perfringens antiserum in the radial vein. The 10 dogs in the control lot received 3-3.5 mg toxin/kg body weight without previous injection of perfringens antiserum. Pressure in the carotid artery and femoral vein were recorded graphically on a cylinder with carbon black and repiration by intubation of the trachea. All the control dogs developed brutal, irreversible shock, dying 120-140 min after administration of the toxin. In the animals previously injected with perfringens antiserum no change occurred in the parameters studied and they survived although the toxin administered was from 2-12 times the lethal dose.

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