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The preventive effect of vitamin E on gallstone formation. (2). A study of the prevention of gallstone formation and protection from liver disorder in hamsters

, : The preventive effect of vitamin E on gallstone formation. (2). A study of the prevention of gallstone formation and protection from liver disorder in hamsters. Nihon Geka Hokan. Archiv für Japanische Chirurgie 56(3): 262-275

A lithogenic diet causes a decrease of the (TBA/CH) ratio in the bile. Hamsters fed a lithogenic diet were administered either an .alpha.-tocopherol solution including polyethylene glycol and hydrogenetic castor oil, or these solvents without .alpha.-tocopherol. .alpha.-Tocopherol produced a decrease in cholesterol, an increase in TBA, and a reduction of lithogenicity, but the solvents had no marked effect. .alpha.-Tocopherol remarkably reduced the incidence of gallstone formation, and a definite inverse correlation was observed between .alpha.-tocopherol in the liver and the lithogenic index of hepatic or gallbladder bile. The lithogenic diet raised serum total cholesterol TG, and PL level, but .alpha.-tocopherol remarkably reduced total cholesterol, TG, VLDL-cholesterol, LDL-TG, VLDL-TG, and VLDL-PL levels. Liver disorders were induced by the continuous addition of 0.5% CDCA to a lithogenic diet. .alpha.Tocopherol increased bile flow, bile acid and phospholipid output, and ameliorated deteriorations in liver function, as measured by GOT and GPT values. Furthermore, it lowered the increased serum TG and total cholesterol levels.

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Accession: 006740672

PMID: 3689083

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