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The primary immune response in bronchial asthma 1. a kinetic study of helix pomatia hemocyanin specific immunoglobulin e immunoglobulin a and immunoglobulin m antibody responses in patients with asthma and matched controls

, : The primary immune response in bronchial asthma 1. a kinetic study of helix pomatia hemocyanin specific immunoglobulin e immunoglobulin a and immunoglobulin m antibody responses in patients with asthma and matched controls. Journal of Allergy and Clinical Immunology 76(1): 29-34

Eleven asthmatic patients with allergy and 10 age- and sex-matched controls were immunized s.c. with 1 mg of the primary test immunogen Helix pomatia hemocyanin (HPH). The HPH-specific IgE, IgG, IgA and IgM antibody response was measured by ELISA [enzyme-linked immunosorbent assay]. After immunization, not only the IgE but also the IgG antibody response of the patients exceeded that of the controls (P < 0.01). IgA antibody response also tended to be higher in the asthmatic group (NS). Except for an earlier rise after immunization in the asthmatic group (P < 0.05). IgM peak responses did not differ significantly between the 2 groups. There was a high correlation (r = 0.9) between the magnitude of the IgE and the IgG antibody responses. IgM antibody response did not correlate with the response in any of the other antibody classes measured. The total serum Ig concentration was determined before immunization. Only the IgE level was significantly higher in the asthmatic group (P < 0.01). No correlation was found between serum Ig concentrations and the magnitude of the HPH-specific antibody response in the same class. The increased humoral responsiveness of asthmatic patients with allergy is not restricted to the IgE class nor to a limited number of commonly encountered antigens (allergens).

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