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The primary immune response in patients with selective immuno globulin a deficiency

, : The primary immune response in patients with selective immuno globulin a deficiency. Clinical & Experimental Immunology 54(3): 778-784

The primary immune response in vitro of 20 patients with selective IgA deficiency was studied and compared to controls. The primary cellular immune response tested by dinitrochlorobenzene (DNCB) was decreased in many patients. The primary humoral immune response was elicited by immunization with the test immunogen Helix pomatia hemocyanin (HPH). Using a direct ELISA [enzyme-linked immunosorbent assay] technique antibodies against HPH of the IgA, IgG and IgM class were measured. Two wk after immunization no response of IgA anti-HPH was seen except in 3 patients who showed a low but detectable antibody level. In spite of normal or even elevated serum IgG and IgM levels there was a significantly lower response of the IgG and IgM anti-HPH antibodies at 2 wk after immunization as compared to the controls followed by a further decline at 6 wk. Selective IgA deficiency is often accompanied by more general disturbances in humoral and cellular immunity to newly encountered antigens.

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