EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The primary immune response in patients with selective immuno globulin a deficiency


Clinical & Experimental Immunology 54(3): 778-784
The primary immune response in patients with selective immuno globulin a deficiency
The primary immune response in vitro of 20 patients with selective IgA deficiency was studied and compared to controls. The primary cellular immune response tested by dinitrochlorobenzene (DNCB) was decreased in many patients. The primary humoral immune response was elicited by immunization with the test immunogen Helix pomatia hemocyanin (HPH). Using a direct ELISA [enzyme-linked immunosorbent assay] technique antibodies against HPH of the IgA, IgG and IgM class were measured. Two wk after immunization no response of IgA anti-HPH was seen except in 3 patients who showed a low but detectable antibody level. In spite of normal or even elevated serum IgG and IgM levels there was a significantly lower response of the IgG and IgM anti-HPH antibodies at 2 wk after immunization as compared to the controls followed by a further decline at 6 wk. Selective IgA deficiency is often accompanied by more general disturbances in humoral and cellular immunity to newly encountered antigens.


Accession: 006740730



Related references

The association of auto immune diseases and anti immuno globulin a antibodies in patients with selective immuno globulin a deficiency. Clinical & Experimental Immunology 37(1): 83-88, 1979

Immuno globulin e in immunologic deficiency diseases part 1 relation of immuno globulin e and immuno globulin a to respiratory tract disease in isolated immuno globulin e deficiency immuno globulin a deficiency and ataxia telangi ectasia. Journal of Clinical Investigation 51(2): 326-330, 1972

Systemic antibody deficiency in patients without serum immuno globulin deficiency or selective immuno globulin a deficiency. Clinical & Experimental Immunology 56(1): 18-22, 1984

Production of immuno globulin g and immuno globulin m antibodies in a secondary response during an increased serotonin level in the body in the period of primary immune response. Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR Seriya Biologicheskikh Nauk (1): 126-130, 1975

Build up and maintenance of immuno globulin g serum concentrations with intra venous immuno globulin in patients with primary humoral immuno deficiency. Vox Sanguinis 43(4): 212-219, 1982

Immuno globulin m deficiency in the immune response of patients with rheumatoid arthritis. Arthritis and Rheumatism 13(3): 214-221, 1970

Effect of specific immuno globulin m antibody on number of immuno globulin g producing cells in primary immune response. Proceedings of the Society for Experimental Biology & Medicine 141(3): 1073-1076, 1972

Heavy chain specific suppression of immuno globulin synthesis and secretion by lymphocytes from patients with selective immuno globulin a deficiency. Journal of Immunology 124(4): 2034-2041, 1980

Disorders of regulatory t cells in patients with selective immuno globulin deficiency and its relationship to associated auto immune phenomena. Clinical & Experimental Immunology 49(2): 410-418, 1982

Immuno globulin m and immuno globulin g rosette formation in the primary and secondary immune response in the system of syngeneic transfer of splenic cells. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 57-60, 1976