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The primary nephrotic syndrome in children identification of patients with minimal change nephrotic syndrome from initial response to prednisone a report of the international study of kidney disease in children


, : The primary nephrotic syndrome in children identification of patients with minimal change nephrotic syndrome from initial response to prednisone a report of the international study of kidney disease in children. Journal of Pediatrics 98(4): 561-564

The accuracy of using the initial response to prednisone in identifying children with minimal glomerular changes was assessed in a prospective study of children between 12 wk and 16 yr of age with the primary nephrotic syndrome. The results indicate that the likelihood is quite high (although not 100%) that a child with the primary nephrotic syndrome who responds during 8 wk of initial intensive steroid treatment has MCNS [minimal change nephrotic syndrome]. Prognosis in these patients can be considered to be very favorable and renal biopsy need not be done unless indicated by the subsequent clinical course. The prediction that a patient who fails to respond has a glomerular lesion other than MCNS would be incorrect in about 1/4 of all patients with the primary nephrotic syndrome, and in as many as 1/2 of patients .ltoreq. 6 yr of age. For these patients, predictions concerning prognosis should be withheld until a renal biopsy provides a histopathologic diagnosis.

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Accession: 006740755

DOI: 10.1016/s0022-3476(81)80760-3

PDF Full Text: The primary nephrotic syndrome in children identification of patients with minimal change nephrotic syndrome from initial response to prednisone a report of the international study of kidney disease in children


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