EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The primary nephrotic syndrome in children identification of patients with minimal change nephrotic syndrome from initial response to prednisone a report of the international study of kidney disease in children






Journal of Pediatrics 98(4): 561-564

The primary nephrotic syndrome in children identification of patients with minimal change nephrotic syndrome from initial response to prednisone a report of the international study of kidney disease in children

The accuracy of using the initial response to prednisone to identify children with minimal glomerular changes has been assessed in a prospective study of children between 12 weeks and 16 years of age with the primary nephrotic syndrome. The results indicate that, as generally held, the likelihood is quite high, although not 100%, that a child with the primary nephrotic syndrome who responds during eight weeks of initial intensive steroid treatment has MCNS. Prognosis in these patients can be considered to be very favorable and renal biopsy need not be done unless indicated by the subsequent clinical course. However, the prediction that a patient who fails to respond has a glomerular lesion other than MCNS would be incorrect in about one-fourth of all patients with the primary nephrotic syndrome, and in as many as one-half of patients less than or equal to 6 years of age. For these patients, predictions concerning prognosis should be withheld until a renal biopsy provides a histopathologic diagnosis.

Accession: 006740755

PMID: 7205481

DOI: 10.1016/s0022-3476(81)80760-3

Download PDF Full Text: The primary nephrotic syndrome in children identification of patients with minimal change nephrotic syndrome from initial response to prednisone a report of the international study of kidney disease in children



Related references

Anonymous, 1981: The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. The accuracy of using the initial response to prednisone to identify children with minimal glomerular changes has been assessed in a prospective study of children between 12 weeks and 16 years of age with the primary nephrotic syndrome. The result...

Anonymous, 1982: Early identification of frequent relapsers among children with minimal change nephrotic syndrome. A report of the International Study of Kidney Disease in Children. An analysis was made of the clinical course of 218 steroid-responsive children with minimal change nephrotic syndrome during the two-year period following initial response to prednisone therapy. No correlation was found between the frequency of re...

Anonymous, 1981: Primary nephrotic syndrome in children: clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity. A Report of the International Study of Kidney Disease in Children. Kidney International 20(6): 765-771

Anon, 1982: The primary nephrotic syndrome in children clinical significance of histo pathologic variants of minimal change and of diffuse mesangial hyper cellularity a report of the international study of kidney disease in children. Kidney International 21(1): 150

Anonymous, 1984: Minimal change nephrotic syndrome in children: deaths during the first 5 to 15 years' observation. Report of the International Study of Kidney Disease in Children. Of 521 children with a previously untreated nephrotic syndrome, as defined by proteinuria greater than or equal to 40 mg/h/m2 and serum albumin less than or equal to 2.5 g/dL, entering the International Study of Kidney Disease in Children between...

Tarshish, P.; Bernstein, J.; Tobin, J.; Edelmann, C.M.Jr, 1993: Course of minimal change nephrotic syndrome A report of the international study of kidney disease in children. Journal of the American Society of Nephrology 4(3): 288

Tarshish, P.; Tobin, J.N.; Bernstein, J.; Edelmann, C.M., 1997: Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. The ability to predict the course in children with newly diagnosed minimal change nephrotic syndrome (MCNS) may have significant therapeutic implications. Previous attempts based on data available at disease onset have not been successful. Therefo...

Norero, C.; Delucchi, A.; Lagos, E.; Rosati, P., 1996: Initial therapy of primary nephrotic syndrome in children: evaluation in a period of 18 months of two prednisone treatment schedules. Chilean Co-operative Group of Study of Nephrotic Syndrome in Children. Ninety six patients aged from 6 months to 15 years and were admitted to Chilean hospitals with the diagnosis of primary nephrotic syndrome in a period of 30 months. These patients were randomly separated in two groups, group A received prednisone...

Anonymous, 1979: Nephrotic syndrome in children: a randomized trial comparing two prednisone regimens in steroid-responsive patients who relapse early. Report of the international study of kidney disease in children. Fifty-four children with steroid-responsive nephrotic syndrome relapsing within 6 months of their initial response were randomly allocated to receive two different regimens of prednisone therapy. The test regimen differed from the standard prednis...

Churg, J.; Habib, R.; White, R.H., 1970: Pathology of the nephrotic syndrome in children: a report for the International Study of Kidney Disease in Children. Lancet 760(1): 1299-1302