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The primary olfactory projection has two chemically distinct zones


, : The primary olfactory projection has two chemically distinct zones. Journal of Neuroscience 6(11): 3393-3404

The sensory neurons of the olfactory epithelium form an anatomically uniform population but are differentially excited by odorants. We have discovered an unexpected biochemical heterogeneity within this population that extends to its axonal projection onto the olfactory bulb. This heterogeneity is recognized by a newly generated monoclonal antibody, designated RB-8, that differentially stains the primary olfactory projection in rats and divides it into 2 nonoverlapping zones.

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Accession: 006740758

PMID: 3772438

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Related references

Gottlieb D.I., 1986: Mab rb 8 that distinguishes chemically distinct zones in primary olfactory projection recognizes 125 kd membrane associated protein. Chemical Senses: 659-660

Schwob J.E.; Gottlieb D.I., 1987: Mouse monoclonal antibody rb 8 that distinguishes chemically distinct zones in the primary olfactory projection recognizes a 125 kilodalton membrane associated protein. Roper S D And J Atema (Ed ) Annals Of The New York Academy Of Sciences, Vol 510 Olfaction And Taste Ix; Ninth International Symposium, Snowmass Village, Colorado, Usa, July 20-24, 1986 Xxii+747p New York Academy Of Sciences: New York, New York, Usa Illus 597-599

Key, B.; Akeson, R.A., 1993: Distinct subsets of sensory olfactory neurons in mouse: possible role in the formation of the mosaic olfactory projection. The axons of the primary sensory olfactory neurons project from the olfactory neuroepithelium lining the nasal cavity, onto glomeruli covering the surface of the olfactory bulb. Neuroanatomical studies have shown previously that individual olfacto...

Reiss, J., O.; Burd, G., D., 1997: Metamorphic remodeling of the primary olfactory projection in Xenopus: Developmental independence of projections from olfactory neuron subclasses. In adult Xenopus, the nasal cavity is divided into separate middle (MC) and principal (PC) cavities; the former is used to smell water-borne odorants, the latter air-borne odorants. Recent work has shown that olfactory neurons of each cavity expre...

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Treloar, H.; Walters, E.; Margolis, F.; Key, B., 1996: Olfactory glomeruli are innervated by more than one distinct subset of primary sensory olfactory neurons in mice. The rodent olfactory epithelium consists of a mosaic of primary sensory olfactory neurons (PONs) which express distinct putative olfactory receptor proteins. Recent evidence suggests that individual subsets of these sensory neurons project to sepa...

Schwob, J.E.; Youngentob, S.L.; Meiri, K.F., 1994: On the formation of neuromata in the primary olfactory projection. Olfactory axons have been shown to grow aberrantly and form dense collections of axons, termed neuromas, in the olfactory epithelium of rats in which the olfactory bulb was ablated. Likewise, in human olfactory mucosa, collections of neurites have...

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