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The primary plasmin inhibitor in rheumatoid synovial fluid


Arthritis and Rheumatism 20(7): 1354-1358
The primary plasmin inhibitor in rheumatoid synovial fluid
In 20 consecutive rheumatoid arthritis patients, 14 women and 6 men, age 26-76, average 62 yr, the concentration of the recently found primary plasmin inhibitor and phase proteins was estimated in plasma and synovial fluid. In 12 patients a complex between the inhibitor and plasmin was demonstrated by crossed immunoelectrophoresis into immunoglobulins against the primary plasmin inhibitor and immunoglobulin against plasminogen. Only free inhibitor was found in corresponding plasma. All plasminogen present in synovial fluid were activated to plasmin upon addition of urokinase (24 nM/1). In those patients where enzyme-inhibitor complex in synovial fluid was present, a higher concentration of phase proteins in synovial fluid was found, indicating an increased degree of inflammation despite identical scores in the Lansbury clinical index in the 2 groups. The fibrinolytic capacity in rheumatoid synovial fluid is probably not decreased. The fibrin-like material in synovial tisse and on the synovial membrane is a poor substrate for plasmin.

Accession: 006740763

PMID: 143941

DOI: 10.1002/art.1780200709

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