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The primary sequence of human pancreatic colipase


, : The primary sequence of human pancreatic colipase. Biochimica et Biophysica Acta 784(1): 75-80

The amino acid sequence of an activated colipase purified from human pancreas was determined. The protein consists of a single polypeptide chain of 86 amino acids (human colipase86) and has a MW of 9289. The sequence was determined by automated Edman degradation of the reduced and S-carboxymethylated protein and of 2 CNBr peptides. Sequence determination of porcine procolipase II was also performed, which showed that in the original sequence determination apparently 2 residues were missed. These residues were determined to be a leucine at position 37 and a serine in position 50. For comparison with porcine and equine procolipases, the residues composing human colipase are numbered from 6-91. No human procolipase has been isolated so far. The colipases from man, pig, horse and chicken show a high degree of homology; human colipase differs from the other proteins by substitutions of 19 (porcine), 24 (equine A) and 21 (equine B) residues, respectively.

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Accession: 006740797

PMID: 6691986

DOI: 10.1016/0167-4838(84)90175-4

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