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The primary serological response to a single dose of adsorbed tetanus toxoid, high concentration type


, : The primary serological response to a single dose of adsorbed tetanus toxoid, high concentration type. Bulletin of the World Health Organization 59(5): 745-752

Single-dose immunization against tetanus was studied in 511 previously non-immunized residents of rural villages in Upper Volta. Males and females were equally represented and a wide age range was covered. A single dose of adsorbed tetanus toxoid containing 17.5 Lf units of toxoid and 3.86 mg of aluminium phosphate per 0.5 ml dose was used. Blood samples were taken 7 days, 2 months, and 12 months after immunization, and serum antitoxin titres were determined by neutralization titrations in mice. Adverse reactions were negligible. Only 2 participants gave evidence of prior immunization by developing detectable antitoxin titres after 7 days; they were eliminated from the study. After 12 months, 59% of the participants had antitoxin titres of >/=0.01 IU/ml, a titre usually considered protective. The mean titre and the proportion of those protected decreased substantially with increasing age; overall, females gave somewhat greater serological responses than males. Mean titre increased by 25% between 2 months and 1 year after immunization; the increase was greater in females than in males. In children under 6 years of age, 100% of females and 82% of males had protective titres after 1 year.

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Accession: 006740801

PMID: 6976235

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Related references

Maclennan R.; Levine L.; Newell K.W.; Edsall G., 1973: The early primary immune response to adsorbed tetanus toxoid in man a study of the influence of antigen concentration carrier concentration and sequence of dosage on the rate extent and persistence of the immune response to 1 and 2 doses of toxoid. Bulletin of the World Health Organization 49(6): 615-626

Levine, L., 1972: A predictive equation for the primary immune response of mice to adsorbed tetanus toxoid as a function of dose of antigen and dose of adjuvant. Journal of Immunology 109(5): 1338-1342

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