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The primary structure of a mono clonal immuno globulin a immuno globulin immuno globulin a tro part 1 the amino acid sequence of the light chain of lambda type subgroup 2


, : The primary structure of a mono clonal immuno globulin a immuno globulin immuno globulin a tro part 1 the amino acid sequence of the light chain of lambda type subgroup 2. Hoppe Seyler's Zeitschrift fuer Physiologische Chemie 356(8): 1333-1336

Human immunoglobulin A [IgA] was isolated from the serum by salt fractionation, ion exchange chromatography and gel filtration. The L-chain was isolated by gel filtration after partial reduction and alkylation of the IgA molecule. The primary structure of the L-chain was determined by sequence studies of its tryptic peptides. The protein containes 216 amino acid residues. Based on its homology with other proteins of known structure, the variable part of the protein belongs to subgroup II of the .lambda.-chains. The constant part of the chain is Kern- and Oz- which means that it has serine in position 154 and arginine in position 191.

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