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The primary structure of epidermal growth factor






Journal of Biological Chemistry 247(23): 7612-7621

The primary structure of epidermal growth factor

A screening test for chronic granulomatous disease is described; it is based on abnormal oxidation of glucose-1-(14)C to (14)CO(2) during phagocytosis by leukocytes in whole blood.


Accession: 006740893

PMID: 4636327

DOI: 10.1080/00221309.1972.9920697



Related references

Shiota K.; Nakamura T.; Ichihara A., 1986: Distinct effects of transforming growth factor beta on epidermal growth factor receptors and epidermal growth factor induced dna synthesis in primary cultured rat hepatocytes. Previous studies showed that transforming growth factor-.beta. (TGF-.beta., 1 ng/ml) strongly inhibited DNA synthesis induced by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. This paper reports that TGF-.beta. (4 ng/m...

García, B.; Neninger, E.; de la Torre, A.; Leonard, I.; Martínez, Río.; Viada, C.; González, G.; Mazorra, Z.; Lage, Aín.; Crombet, T., 2008: Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine. Epidermal growth factor (EGF) might be a suitable immunotherapeutic target in non-small-cell lung cancer (NSCLC). Our approach consists of active immunotherapy with EGF. The aim of the study is to characterize the humoral response and its effects...

Bax, B.; Blaber, M.; Ferguson, G.; Sternberg, M.J.; Walls, P.H., 1993: Prediction of the three-dimensional structures of the nerve growth factor and epidermal growth factor binding proteins (kallikreins) and an hypothetical structure of the high molecular weight complex of epidermal growth factor with its binding protein. We have predicted the three-dimensional structures of the serine protease subunits (gamma-NGF, alpha-NGF, and EGF-BP) of the high molecular weight complexes of nerve growth factor (7S NGF) and epidermal growth factor (HMW-EGF) from the mouse subma...

Bax, B.; Blaber, M.; Ferguson, G.; Sternberg, M.J.E.; Walls, P.H., 1993: Prediction of the three-dimensional structures of the nerve growth factor and epidermal growth factor binding proteins and an hypothetical structure of the high molecular weight complex of epidermal growth factor with its binding protein. We have predicted the three-dimensional structures of the serine protease subunits (gamma-NGF, alpha-NGF, and EGF-BP) of the high molecular weight complexes of nerve growth factor (7S NGF) and epidermal growth factor (HMW-EGF) from the mouse subma...

Filmus J.; Pollak M.N.; Cailleau R.; Buick R.N., 1985: Mda 648 a human breast cancer cell line with a high number of epidermal growth factor receptors has an amplified epidermal growth factor receptor gene and is growth inhibited by epidermal growth factor. Epidermal growth factor (EGF) was noted to stimulate proliferation of a variety of normal and malignant cells including those of human breast epithelium. MDA-468, a human breast cancer cell line with a very high number of EGF receptors, is growth-...

Ray, P.; Moy, F.J.; Montelione, G.T.; Liu, J.F.; Narang, S.A.; Scheraga, H.A.; Wu, R., 1988: Structure-function studies of murine epidermal growth factor: expression and site-directed mutagenesis of epidermal growth factor gene. Wild-type murine epidermal growth factor (mEGF) and mutants with Leu47 replaced by serine and valine, respectively, have been produced by recombinant DNA methodology. A synthetic gene for mEGF was fused to the coding sequence for the signal peptid...

Gill, G.N.; Kawamoto, T.; Cochet, C.; Le, A.; Sato, J.D.; Masui, H.; McLeod, C.; Mendelsohn, J., 1984: Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. Four mouse monoclonal antibodies specific for human epidermal growth factor (EGF) receptors have been prepared using EGF receptor protein from human A431 epidermoid carcinoma cells as immunogen. We have determined the effect of these antibodies on...

Kahan, Z.; Szucs, M.; Vecsernyes, M.; Eckhardt, S., 1993: Epidermal growth factor-like activity and epidermal growth factor-receptors in human primary breast cancer. Ligands binding to epidermal growth factor-receptors (EGF-Rs) as epidermal growth factor-like activity (EGF-like activity), along with EGF-R levels, were determined from human primary breast cancer samples. Receptor analysis revealed a single clas...

Castellanos L.; Estrada R., 1991: Characterization of the primary structure of recombinant human epidermal growth factor. Human Epidermal Growth Factor (EGF) expressed in Saccharomyces cerevisiae was analyzed by reversed phase liquid chromatography. Two main components were isolated and studied by amino acid analysis, NH2-terminal sequence and peptide mapping. The lo...

Weir, E.; Chen, Q.; DeFrances, M.C.; Bell, A.; Taub, R.; Zarnegar, R., 1994: Rapid induction of mRNAs for liver regeneration factor and insulin-like growth factor binding protein-1 in primary cultures of rat hepatocytes by hepatocyte growth factor and epidermal growth factor. Liver regeneration factor belongs to the leucine-zipper family of transcription factors. It was originally cloned and characterized through differential screening of a regenerating rat liver cDNA library. The mRNA for liver regeneration factor-1 i...