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The primary structure of human complement c 4 carboxyl terminal peptides


, : The primary structure of human complement c 4 carboxyl terminal peptides. Bioscience Reports 5(10-11): 913-922

C-terminal CNBr peptides of the three polypeptide chains of C4 were obtained and sequenced. These results supplement previously obtained data, notably the protein sequence derived from cDNA sequencing of pro-C4 (Belt KT, Carroll MC and Porter RR (1984) Cell 36, 907-914) and the N-terminal sequences of the three polypeptides (Gigli I, von Zabern I and Porter RR (1977) Biochem. K. 165, 439-446), to define the complete primary structure of the plasma form of C4. The .beta. (656 residues), .alpha. (748 residues), and .gamma. (291 residues) chains are found in positions 1-656, 661-1408, and 1435-1725 in the pro-C4 molecule.

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