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The ratio of plasma high density lipoprotein cholesterol to total and low density lipoprotein cholesterol age related changes and race and sex differences in selected north american populations the lipid research clinics program prevalence study



The ratio of plasma high density lipoprotein cholesterol to total and low density lipoprotein cholesterol age related changes and race and sex differences in selected north american populations the lipid research clinics program prevalence study



Circulation 72(1): 93-104



There is a strong association between elevated blood concentrations of total cholesterol and the subsequent development of ischemic heart diseases. The distribution of the ratios of plasma high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) and of HDL-C to low-density lipoprotein cholesterol (LDL-C) are presented for 6900 white and 495 black examinees > 4 yr old. Measurements were obtained during the visit 2 survey of the Lipid Research Clinics (LRC) Program Prevalence Study, and correspond to a 15% random sample of 60,502 participants screened during the LRC visit 1 survey. Age-specific means, medians and selected percentiles are given by sex and by gonadal hormone use in white women. Apparent in these cross-sectional data was a consistent age-related decline in the ratio of HDL-C to TC for white male participants, from a mean of 0.360 in the age group 5-9 to a mean of 0.211 in the age group 50-54. Thereafter the mean ratio increased slightly. In white women not using gonadal hormones the age-related decline in the ratio was only evident starting at the age group 35-39, from which it declines from 0.329 to 0.258 in the age group 55-59. White women using gonadal hormones showed very minor age-related changes in the HDL-C/TC ratio, varying around a mean of 0.300. The number of blacks examined was low and thus the racial comparisons must be interpreted with caution. For each gender, agea-related trends were similar in black and white study participants. Black men had a higher percentage of TC carried as HDL-C than white men in all age groups examined. Black women had a higher percentage of TC in HDL-C than white women only < 20; in the adult age range no appreciable differences were seen. Pearson correlation coefficients between the lipid, lipoprotein and lipoprotein ratios are presented. The ratio HDL-C/TC correlated highly with the ratio HDL-C/LDL-C (> 0.92 for all groups) and the former may be a more conveniently determined surrogate for the latter. Although not exhaustive regarding the information it conveys about a lipid pattern, the ratio HDL-C/TC has the advantage of summarizing complex associations into a single numerical approximation.

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Accession: 006746511

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PMID: 4006139


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