The release of endogenous amino acids from rat visual cortex by calcium ions in the presence of the calcium ionophore x 537a and ionophore a 23187

Collins, G.G.S.

Journal of Neurochemistry 28(2): 461-464


ISSN/ISBN: 0022-3042
Accession: 006752701

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The results in which Ca in the presence of a calcium ionophore released the physiologically active amino acids glutamate and GABA are in agreement with the suggestion that these compounds are neurotransmitters within the brain. Aspartate release was enhanced only in the presence of X537A which is known to be less specific in transporting Ca2+ than is A23187. The Ca-evoked release of taurine in the presence of either ionophore is clearly at variance with earlier results and so the possibility of taurine being a neurotransmitter in the rat brain must for the moment remain an open question.